238 results found
    1. Neuroscience

    Emotional learning retroactively promotes memory integration through rapid neural reactivation and reorganization

    Yannan Zhu, Yimeng Zeng ... Shaozheng Qin
    Emotional learning retroactively promotes memory integration for previously neutral events into episodic memory to foster future event predictions, through rapidly stimulating trial-specific reactivation of overlapping memory traces and reorganization of associated memories among the amygdala, hippocampal, and neocortical circuits.
    1. Cell Biology
    2. Neuroscience

    Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release

    Zhao Xuan, Laura Manning ... Peri T Kurshan
    Clarinet, a novel C. elegans active zone protein with homology to vertebrate Piccolo and Rim, uses its different isoforms for diverse functions, including synaptic vesicle clustering, vesicle release and synaptogenesis.
    1. Cell Biology
    2. Developmental Biology

    EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity

    Maike Frye, Simon Stritt ... Taija Mäkinen
    EphrinB2/EphB4-mediated regulation of cytoskeletal contractility is a key homeostatic mechanism of lymphatic endothelial cell-cell junction maintenance, and provides a potential target for therapeutic modulation of lymphatic vessel permeability and function.
    1. Neuroscience

    Molecular characterization of projection neuron subtypes in the mouse olfactory bulb

    Sara Zeppilli, Tobias Ackels ... Alexander Fleischmann
    Different subtypes of projection neurons in the mouse olfactory bulb are defined by distinct gene expression patterns and transcription factor networks.
    1. Genetics and Genomics
    2. Neuroscience

    Thirst interneurons that promote water seeking and limit feeding behavior in Drosophila

    Dan Landayan, Brian P Wang ... Fred W Wolf
    Thirsty seeking interneurons in Drosophila differentially regulate water intake and feeding behavior.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Complementary shifts in photoreceptor spectral tuning unlock the full adaptive potential of ultraviolet vision in birds

    Matthew B Toomey, Olle Lind ... Joseph C Corbo
    Birds that see ultraviolet light tune the sensitivity of their short-wavelength photoreceptors with colored filters to maximize the number of colors they can see.
    1. Neuroscience

    Functionally asymmetric motor neurons contribute to coordinating locomotion of Caenorhabditis elegans

    Oleg Tolstenkov, Petrus Van der Auwera ... Alexander Gottschalk
    The 'missing' class of Caenorhabditis elegans excitatory motor neurons, AS, contribute to propagation and coordination of body waves, integrating information from, and feeding back to premotor interneurons byelectrical signaling.
    1. Neuroscience
    2. Physics of Living Systems

    A theory of synaptic transmission

    Bin Wang, Olga K Dudko
    The analytic theory establishes the general principles of synaptic transmission, enables extraction of microscopic parameters of synaptic fusion machinery from experiments, and links molecular constituents to synaptic function.
    1. Neuroscience

    The cellular architecture of memory modules in Drosophila supports stochastic input integration

    Omar A Hafez, Benjamin Escribano ... Jan Pielage
    Computational modeling of a central decision neuron of Drosophila reveals an electrotonically compact architecture that is ideally suited to support efficient memory storage within a stochastically connected memory circuit.
    1. Computational and Systems Biology
    2. Neuroscience

    Graphical-model framework for automated annotation of cell identities in dense cellular images

    Shivesh Chaudhary, Sol Ah Lee ... Hang Lu
    Unbiased and automatic annotation using structured prediction framework with efficiently built data-driven atlases is more accurate than registration-based methods for cell identifications in dense images and enables fast whole-brain analysis.

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