238 results found
    1. Neuroscience

    Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice

    Laura Dean Heckman, Maria H Chahrour, Huda Y Zoghbi
    Transgenic mice with Rett-causing mutations in MeCP2 reveal that a basic cluster in the C-terminus of the protein binds DNA and that both the methyl-CpG binding domain and the transcriptional repression domain are necessary to elicit toxicity in MECP2 duplication syndrome.
    1. Ecology
    2. Neuroscience
    Silhouette of a zebra finch on a blue background.

    The Natural History of Model Organisms: Neurogenomic insights into the behavioral and vocal development of the zebra finch

    Mark E Hauber, Matthew IM Louder, Simon C Griffith
    The genetic and behavioral diversity of the zebra finch, both in the wild and in captivity, make it well-suited for neuroethological studies of vocal learning, culture, and social bonding.
    1. Developmental Biology
    2. Neuroscience

    Sequential addition of neuronal stem cell temporal cohorts generates a feed-forward circuit in the Drosophila larval nerve cord

    Yi-wen Wang, Chris C Wreden ... Ellie Heckscher
    A newly identified pattern of circuit assembly shows connectivity between small groups of neurons born in tight time windows from different stem cells, with outputs from one lineage born before inputs from other lineages.
    1. Evolutionary Biology
    2. Neuroscience

    Divergent sensory investment mirrors potential speciation via niche partitioning across Drosophila

    Ian W Keesey, Veit Grabe ... Bill S Hansson
    Phototaxis and courtship behavioral preferences reflect strong correlation with differences in olfactory and visual nervous system investment across five monophyletic Drosophila species, and could help explain their speciation events.
    1. Computational and Systems Biology
    2. Neuroscience

    Automatically tracking feeding behavior in populations of foraging C. elegans

    Elsa Bonnard, Jun Liu ... Monika Scholz
    A new tool enables measuring feeding and locomotion simultaneously which will enable insights into environmental, developmental, neuronal, and genetic factors underlying behavioral regulation.
    1. Developmental Biology
    2. Neuroscience

    How prolonged expression of Hunchback, a temporal transcription factor, re-wires locomotor circuits

    Julia L Meng, Zarion D Marshall ... Ellie S Heckscher
    In vivo stem cell reprogramming in the well-studied stem cell NB7-1 using the classic temporal transcription factor Hunchback increases motor neuron number and re-specifies dendritic morphology and neuromuscular synaptic partnerships.
    1. Developmental Biology
    2. Neuroscience

    Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships

    Julia L Meng, Yupu Wang ... Ellie S Heckscher
    Acting in neuronal stem cells, temporal transcription factors, as a class of molecules, are uniquely potent determinants of circuit membership that establish expected patterns of wiring in the motor system.
    1. Developmental Biology

    A gradient of Wnt activity positions the neurosensory domains of the inner ear

    Magdalena Żak, Nicolas Daudet
    Manipulations of Wnt signalling in the chicken embryo reveal how it controls in a dose-dependent manner the formation of the neurosensory territories of the early developing inner ear.
    1. Evolutionary Biology
    2. Neuroscience

    Evolution: Shining a light on the origin of fly species

    Hui Gong, Lucia Prieto-Godino
    Natural light gradients within a habitat may have helped form new fly species that have differing preferences for light.
    Version of Record
    Insight

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