Laura Dean Heckman, Maria H Chahrour, Huda Y Zoghbi
Transgenic mice with Rett-causing mutations in MeCP2 reveal that a basic cluster in the C-terminus of the protein binds DNA and that both the methyl-CpG binding domain and the transcriptional repression domain are necessary to elicit toxicity in MECP2 duplication syndrome.
Mark E Hauber, Matthew IM Louder, Simon C Griffith
The genetic and behavioral diversity of the zebra finch, both in the wild and in captivity, make it well-suited for neuroethological studies of vocal learning, culture, and social bonding.
A newly identified pattern of circuit assembly shows connectivity between small groups of neurons born in tight time windows from different stem cells, with outputs from one lineage born before inputs from other lineages.
Phototaxis and courtship behavioral preferences reflect strong correlation with differences in olfactory and visual nervous system investment across five monophyletic Drosophila species, and could help explain their speciation events.
A new tool enables measuring feeding and locomotion simultaneously which will enable insights into environmental, developmental, neuronal, and genetic factors underlying behavioral regulation.
Julia L Meng, Zarion D Marshall ... Ellie S Heckscher
In vivo stem cell reprogramming in the well-studied stem cell NB7-1 using the classic temporal transcription factor Hunchback increases motor neuron number and re-specifies dendritic morphology and neuromuscular synaptic partnerships.
Acting in neuronal stem cells, temporal transcription factors, as a class of molecules, are uniquely potent determinants of circuit membership that establish expected patterns of wiring in the motor system.
Manipulations of Wnt signalling in the chicken embryo reveal how it controls in a dose-dependent manner the formation of the neurosensory territories of the early developing inner ear.