220 results found
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival in tuberculous meningitis

    Laura Whitworth et al.
    In this ideal example of pharmacogenomics, individuals with a common variant in a gene encoding for an inflammatory lipid mediator benefit selectively from standard-of-care anti-inflammatory treatment used for tuberculous meningitis.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain

    Kelda Chia et al.
    Pre-neoplastic cells in the brain release SDF1, which mediates an immediate infiltration of macrophages that differentiate into microglia-like cells and promote proliferation of pre-neoplastic cells.
    1. Immunology and Inflammation
    2. Medicine

    An open label trial of anakinra to prevent respiratory failure in COVID-19

    Evdoxia Kyriazopoulou et al.
    Early suPAR-guided anakinra decreases the risk for severe respiratory failure in SARS-CoV-2 pneumonia and restores the pro-/anti-inflammatory balance.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Aberrant corticosteroid metabolism in tumor cells enables GR takeover in enzalutamide resistant prostate cancer

    Jianneng Li et al.
    Prostate cancer resistance to androgen receptor antagonist therapy occurs by way of tumors impeding local glucocorticoid metabolism and inactivation and thereby permitting sustained glucocorticoids to stimulate up-regulated glucocorticoid receptor.
    1. Stem Cells and Regenerative Medicine

    Stem cells repurpose proliferation to contain a breach in their niche barrier

    Kenneth Lay et al.
    Adult stem cells sense nearby tissue damage and recruit immune cells to help them direct efforts towards containing a breach in the epithelial barrier.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    AAV ablates neurogenesis in the adult murine hippocampus

    Stephen Johnston et al.
    Future work using recombinant AAV as an experimental tool in the dentate gyrus or as a gene therapy for diseases of the central nervous system should be carefully evaluated.
    1. Immunology and Inflammation
    2. Neuroscience

    Drainage of inflammatory macromolecules from the brain to periphery targets the liver for macrophage infiltration

    Linlin Yang et al.
    Circulation of molecules from the brain can serve as a rapid mode of communication from the brain to the liver.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    An internal thioester in a pathogen surface protein mediates covalent host binding

    Miriam Walden et al.
    Bacterial-encoded covalent adhesion is a new molecular principle in host-microbe interactions and may play a key role in host colonization by a wide range of Gram-positive bacteria.
    1. Stem Cells and Regenerative Medicine

    Distinct skeletal stem cell types orchestrate long bone skeletogenesis

    Thomas H Ambrosi et al.
    Functional and molecular analyses of two distinct skeletal stem cell populations establish the important role of stem cell diversity that provides a framework for novel investigations into skeletal biology.
    1. Microbiology and Infectious Disease
    2. Medicine

    A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults

    Nguyen TH Mai et al.
    Adjunctive aspirin may reduce new brain infarcts and deaths in the first 60 days of treatment for HIV-uninfected adults with tuberculous meningitis.

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