Text mining of complete EHRs for 14,017 diabetes patients and subsequent clustering led to phenotypically deep clusters, showing distinct glycemic profiles, comorbidities, and SNP association patterns.

A subpopulation of multi-secretory hypothalamic stem cells was developed to form 3D spheres for peripheral application against mortality and symptom of a severe diabetes model.

A GWAS meta-analysis for OPLL identified fourteen significant genomic loci and a subsequent Mendelian randomization study provided genetic evidence for a causal effect of obesity on the pathogenesis of OPLL, especially one of its subtypes, thoracic OPLL.

Patients diagnosed with a cardiovascular disease are at higher risk of psychiatric disorders, independent of familial factors shared between full siblings and comorbid conditions.

Humans with mutations in the AIRE gene exhibit common autoantibodies targeting ovarian and intestinal antigens, including intestinal dysfunction-associated antibodies to enteroendocrine transcription factor RFX6.

Sociodemographic (age, race/ethnicity) and clinical (Eastern Cooperative Oncology Group performance status, pre-existing comorbidities, and active and progressing cancer) risk factors were associated with worse COVID-19 outcomes in patients with breast cancer.

A chemical biology approach has identified the kinase DYRK1A as a new regulator of the inflammatory response.

The associations of egg consumption with metabolic markers and of these markers with cardiovascular disease (CVD) risk showed opposite directions, which may partially explain the protective effect of moderate egg consumption on CVD in the Chinese population.

Genomic differences in stroke and its comorbid conditions can aid in refining the socio-economic interpretation of risk among different ethnicities and can assist in distinguishing their phenotypic variation.

First influenza infections determine susceptibility to future seasonal influenza infection throughout life, and may impact vaccine effectiveness.