1,886 results found
    1. Human Biology and Medicine

    Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist

    Nicolas Damond et al.
    Contrary to previous reports, a complete absence of glucagon signaling is not sufficient to prevent diabetes after near-total β-cell loss.
    1. Human Biology and Medicine

    Increase in clinically recorded type 2 diabetes after colectomy

    Anders B Jensen et al.
    This nationwide register-based study of diabetes risk after colectomy suggests that the left colon contributes to maintenance of glucose homeostasis.
    1. Genetics and Genomics

    Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

    Matthias Thurner et al.
    Human pancreatic islet high-resolution chromatin state maps generated from DNA methylation, open chromatin and ChIP-seq mark data facilitate the characterisation of regulatory mechanisms at type 2 diabetes genome-wide association study loci.
    1. Immunology and Inflammation

    Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells

    Wenxian Fu et al.
    A short treatment of the NOD mouse model of type-1 diabetes with I-BET151, a small molecule bromodomain blocker, provides long-term protection from disease by inducing macrophages to adapt an anti-inflammatory tenor whilst promoting islet β cell regeneration.
    1. Immunology and Inflammation

    Autoimmunity: Treating type-1 diabetes with an epigenetic drug

    Yohko Kitagawa, Naganari Ohkura
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    1. Cell Biology
    2. Developmental Biology

    The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes

    Ying-Ju Chang et al.
    PDZ-RhoGEF controls adipose tissue abundance and whole body metabolism.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Diabetes regulates fructose absorption through thioredoxin-interacting protein

    James R Dotimas et al.
    Thioredoxin-Interacting Protein binds directly to fructose transporters and regulates fructose metabolism, both acutely and chronically.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity

    Xue-Song Zhang et al.
    Alteration of host gut microbiota by antibiotic exposure in early life remodeled host intestinal immune development and metabolism and enhanced the induction of type 1 diabetes in genetically predisposed animals.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Anti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM

    Gregory M Martin et al.
    A structure of a pancreatic ATP-sensitive potassium channel complex at 3.63Å resolution obtained by cryo-electron microscopy reveals how a commonly used anti-diabetic drug interacts with and inhibits the channel to stimulate insulin secretion.
    1. Developmental Biology
    2. Epidemiology and Global Health

    Corrupted adipose tissue endogenous myelopoiesis initiates diet-induced metabolic disease

    Elodie Luche et al.
    Adipose tissue derived hematopoietic stem cells from diabetic mice transplanted into healthy animals on a normal diet increase inflammation in adipose tissue and trigger the development of a diabetic state in the recipient animals.

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