1,172 results found
    1. Chromosomes and Gene Expression

    The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

    Yuan Zhang et al.
    Transgenic mice with high levels of FGF21 live for longer than wild-type mice and do so without reducing food intake.
    1. Structural Biology and Molecular Biophysics

    Molecular architecture of human polycomb repressive complex 2

    Claudio Ciferri et al.
    Electron microscopy has been used to produce the first three-dimensional image of the PRC2 gene-silencing complex.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex

    Tsutomu Aoki et al.
    A chromatin boundary factor that is only active during early embryo development has been discovered in Drosophila.
    1. Human Biology and Medicine
    2. Microbiology and Infectious Disease

    Global divergence in critical income for adult and childhood survival: analyses of mortality using Michaelis–Menten

    Ryan J Hum et al.
    A mathematical model based on enzyme kinetics shows how the relationships between life expectancy, survival rates for children and adults, and national income change over time.
  1. Point of View: Basic research at the epicenter of an epidemic

    William R Bishai
    William R Bishai, director of the KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH), argues that the best place to carry out research into a disease is in its midst.
    1. Human Biology and Medicine

    Overcoming mutation-based resistance to antiandrogens with rational drug design

    Minna D Balbas et al.
    Mutagenesis studies identified an androgen receptor mutation that converts enzalutamide-a drug recently approved for the treatment of advanced prostate cancer-into an androgen receptor agonist, and modeling studies informed the design of novel drugs that are effective against the mutant receptor.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

    Jiajie Diao et al.
    Experiments on synthetic models of synaptic vesicles have shed new light on the role of the protein α-synuclein in the central nervous system.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage

    Ashley L St John et al.
    Proteins produced by mast cells modulate the permeability of blood vessels, and may determine whether patients infected with dengue virus develop life-threatening complications.
    1. Epidemiology and Global Health

    Predicting mosquito infection from Plasmodium falciparum gametocyte density and estimating the reservoir of infection

    Thomas S Churcher et al.
    Identifying and treating those groups of individuals that are most likely to transmit the malaria parasite to mosquitoes could help to control the spread of the disease.

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