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    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

    James A Watson et al.
    Complete blood count data can increase the accuracy of the diagnosis of severe malaria in children in high transmission settings.
    1. Computational and Systems Biology

    Dynamics of preventive vs post-diagnostic cancer control using low-impact measures

    Andrei R Akhmetzhanov, Michael E Hochberg
    A model based on empirical parameter estimates predicts that arresting cancer cell growth by less than 1% per day will produce optimal outcomes in preventing life-threatening cancers, and that such preventive measures are generally more successful than post-diagnostic interventions.
    1. Computational and Systems Biology
    2. Medicine

    Diagnostically relevant facial gestalt information from ordinary photos

    Quentin Ferry et al.
    An automatic computer vision analysis approach can assist in the diagnosis of rare genetic disorders by using ordinary photographs of patients.
    1. Cell Biology

    Intelligent classification of platelet aggregates by agonist type

    Yuqi Zhou et al.
    An intelligent method is developed to morphologically classify platelet aggregates by agonist type, which potentially opens a window on novel clinical diagnostics and therapeutics of thrombotic disorders.
    1. Medicine
    2. Neuroscience

    Stimulus-induced gamma rhythms are weaker in human elderly with mild cognitive impairment and Alzheimer’s disease

    Dinavahi VPS Murty et al.
    Visual narrow-band gamma rhythms are reduced in mild cognitive impairment and Alzheimer’s disease, confirming previous rodent research and forming crucial first steps for development of EEG-based biomarkers for humans.
    1. Genetics and Genomics

    Repurposing eflornithine to treat a patient with a rare ODC1 gain-of-function variant disease

    Surender Rajasekaran et al.
    Genetic sequencing has led to the increased diagnoses of rare diseases, strategies such as repurposing drugs and global metabolomics offer promise and bring hope to afflicted families.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Point of View: Tuberculosis innovations mean little if they cannot save lives

    Madhukar Pai, Jennifer Furin
    Ending the TB epidemic requires scaling up access to new TB tools so that they can benefit the patients in low- and middle-income countries that need them the most.
    1. Epidemiology and Global Health

    Impact of seasonal variations in Plasmodium falciparum malaria transmission on the surveillance of pfhrp2 gene deletions

    Oliver John Watson et al.
    The timing of surveillance for pfhrp2/3-deletions within a transmission season impacts estimates of the proportion of false-negative RDTs due to deletions, which may cause premature decisions to change RDT.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Salmonella Typhi and Salmonella Paratyphi A elaborate distinct systemic metabolite signatures during enteric fever

    Elin Näsström et al.
    Metabolite analysis of plasma from enteric fever patients define signals of organism specific host–pathogen interactions and provides opportunities for new diagnostics.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Targeted surveillance strategies for efficient detection of novel antibiotic resistance variants

    Allison L Hicks et al.
    Sampling informed by pathogen genomic data may facilitate more efficient detection of novel antibiotic resistance than random sampling.