Konrad Lang, Julian Milosavljevic ... Tobias Hermle
To maintain the filtration barrier, slit diaphragms are cleansed by rapid cycles of raft-mediated endocytosis, while dynamin-dependent endocytosis prevents lateral diffusion of slit diaphragm protein.
Elizabeth M Sefton, Mirialys Gallardo ... Gabrielle Kardon
HGF derived from fibroblasts is critical for complete muscularization of the mammalian diaphragm, and loss-of-function experiments reveal that partial muscularization of the diaphragm is not sufficient to cause congenital diaphragmatic hernias.
Camille Charoy, Sarah Dinvaut ... Valerie Castellani
Analysis of embryonic mouse diaphragm reveals muscle and nerve left–right asymmetries set by a Nodal-dependent genetic cascade, which imprints different molecular signatures to left and right motoneurons that shape their innervation pattern.
Mark W Urban, Brittany A Charsar ... Angelo C Lepore
In the SOD1G93A mouse model of amyotrophic lateral sclerosis (ALS), expression of transmembrane signaling molecule ephrinB2 in spinal cord astrocytes contributes to motor neuron damage and loss of diaphragm function.
Arun Sharma, Lauren K Wasson ... Pediatric Cardiac Genomics Consortium
Analyses of human stem cells with distinct GATA6 mutations revealed a spectrum of molecular responses that drive isolated congenital heart disease or the co-occurrence of pancreas and diaphragm malformations.
Genetic mouse models combined with single-cell RNA sequencing reveal the essential role of SRSF2 in directing MyoD progenitors to distinct skeletal muscle domains and controlling their differentiation through the regulation of targeted genes and alternative splicing during skeletal muscle development.
Expression of the transcription factor Wt1 is required in a lateral mesoderm domain to develop the mesenchymal population required for the closure of the pleural cavities and the formation of the diaphragm.
A combination of advanced optical imaging and cryogenic electron microscopy has been used to explore membrane fusion in a synthetic system and provide new insights into neurotransmitter release.
Abl2 regulates myoblast proliferation, thereby controlling the size of the pool of myoblasts available for fusion, providing insight into mechanisms that control myofiber length and signaling between muscle and tendon.
