165 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Large domains of heterochromatin direct the formation of short mitotic chromosome loops

    Maximilian H Fitz-James et al.
    Large regions of foreign DNA inserted into mammalian chromosomes assemble into H3K9me3-heterochromatin and result in increased condensin loading with organisation into shorter mitotic chromosome loops than endogenous DNA.
    1. Chromosomes and Gene Expression

    Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments

    Hajnalka L Pálinkás et al.
    Human genomic DNA contains uracil in the late replicating, constitutive heterochromatic regions, while treatment with drugs perturbing thymidylate biosynthesis shifts the uracil distribution pattern towards the euchromatin in UNG-inhibited cells.
    1. Chromosomes and Gene Expression

    Differentiating Drosophila female germ cells initiate Polycomb silencing by regulating PRC2-interacting proteins

    Steven Z DeLuca et al.
    Characterization of Drosophila female germ cell differentiation shows that nurse cells initiate Polycomb silencing by regulating Pcl and Scm levels to alter the biochemical properties of the PRC2 H3K27 methylase.
    1. Chromosomes and Gene Expression

    Caenorhabditis elegans nuclear RNAi factor SET-32 deposits the transgenerational histone modification, H3K23me3

    Lianna Schwartz-Orbach et al.
    H3K23me3 is a RNAi-mediated transgenerationally heritable heterochromatin mark in Caenorhabditis elegans.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    S-phase-independent silencing establishment in Saccharomyces cerevisiae

    Davis Goodnight, Jasper Rine
    Cell-cycle progression is crucial for heterochromatin formation in budding yeast because S phase promotes the removal of active chromatin marks.
    1. Cancer Biology
    2. Cell Biology

    Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation

    Ashna Alladin et al.
    The presented primary epithelial acinus-based platform for studying interactions between normal and malignant cells will enable in depth analysis of the tumor initiation process on a molecular level.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations

    Lucas Farnung et al.
    The structure of the chromatin remodeller CHD4 bound to a nucleosome reveals differences to the known Chd1-nucleosome complex and maps cancer mutations.
    1. Neuroscience

    Fast and reversible neural inactivation in macaque cortex by optogenetic stimulation of GABAergic neurons

    Abhishek De et al.
    Optogenetic activation of cortical GABAergic cells in macaques yields robust and reversible behavioral deficits.
    1. Evolutionary Biology
    2. Neuroscience

    True S-cones are concentrated in the ventral mouse retina and wired for color detection in the upper visual field

    Francisco M Nadal-Nicolás et al.
    Unique 'true' S-cone and S-cone bipolar cell distribution patterns in the mouse retina are previously unappreciated anatomical features that support enhanced short-wavelength signaling for color detection above horizon.
    1. Physics of Living Systems

    Measuring ligand-cell surface receptor affinities with axial line-scanning fluorescence correlation spectroscopy

    Antonia Franziska Eckert et al.
    A robust fluorescence microscopy-based data acquisition and analysis framework affords the precise measurement of cell surface receptor affinities toward their cognate ligands and their densities in live cells/tissues.

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