265 results found
    1. Chromosomes and Gene Expression

    miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila

    Manish Pandey et al.
    miR-125 functions as a potential dietary restriction mimetic by promoting longevity through regulation of fat metabolism.
    1. Evolutionary Biology
    2. Medicine

    A dietary sterol trade-off determines lifespan responses to dietary restriction in Drosophila melanogaster females

    Brooke Zanco et al.
    Micronutrients, not macronutrients, regulate lifespan.
    1. Developmental Biology
    2. Immunology and Inflammation

    Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction

    Jennifer C Regan et al.
    In the fruit fly Drosophila melanogaster, stem cell activity ages female guts but not male guts; furthermore, males with feminized guts develop pathologies but gain an increase in lifespan through dietary restriction.
    1. Chromosomes and Gene Expression

    Serotonin signaling mediates protein valuation and aging

    Jennifer Ro et al.
    Serotonin modulates diet-dependent lifespan in flies.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice

    Jason D Plummer et al.
    Dietary selenium supplementation confers to mice all of the short-term healthspan benefits of the longevity-promoting intervention methionine restriction, and thus may represent a method to promote healthy aging in mammals.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Sir2 phosphorylation through cAMP-PKA and CK2 signaling inhibits the lifespan extension activity of Sir2 in yeast

    Woo Kyu Kang et al.
    The deacetylase Sir2 fine-tunes transcription of PMA1 and other aging related genes in a cAMP-PKA and CK2 signaling dependent manner.
    1. Neuroscience

    A gene-expression-based neural code for food abundance that modulates lifespan

    Eugeni V Entchev et al.
    TGFβ and serotonin signaling in a neural circuit encodes food availability; these signals regulate the dynamic range and variability on the circuit to impact coding accuracy and lifespan responses.
    1. Biochemistry and Chemical Biology

    Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation

    Andrei S Avanesov et al.
    Aging is a process characterized by gradual metabolome remodeling, deceleration of the remodeling in late life and under conditions that extend lifespan, and a mortality-associated pattern of cumulative damage.
    1. Developmental Biology
    2. Genetics and Genomics

    celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish

    Chunmei Li et al.
    The use of forward genetic screens in zebrafish identifies a new model of vertebrate aging, defining the regulating of the onset of aging phenotypes through maintenance of progenitor cell populations.
    1. Genetics and Genomics

    Drosophila serotonin 2A receptor signaling coordinates central metabolic processes to modulate aging in response to nutrient choice

    Yang Lyu et al.
    Dietary choice per se is sufficient to modulate aging in Drosophila and through serotonergic control of peripheral metabolism.

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