163 results found
    1. Developmental Biology
    2. Immunology and Inflammation

    Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction

    Jennifer C Regan et al.
    In the fruit fly Drosophila melanogaster, stem cell activity ages female guts but not male guts; furthermore, males with feminized guts develop pathologies but gain an increase in lifespan through dietary restriction.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Sir2 phosphorylation through cAMP-PKA and CK2 signaling inhibits the lifespan extension activity of Sir2 in yeast

    Woo Kyu Kang et al.
    The deacetylase Sir2 fine-tunes transcription of PMA1 and other aging related genes in a cAMP-PKA and CK2 signaling dependent manner.
    1. Neuroscience

    A gene-expression-based neural code for food abundance that modulates lifespan

    Eugeni V Entchev et al.
    TGFβ and serotonin signaling in a neural circuit encodes food availability; these signals regulate the dynamic range and variability on the circuit to impact coding accuracy and lifespan responses.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Serotonin signaling mediates protein valuation and aging

    Jennifer Ro et al.
    Serotonin modulates diet-dependent lifespan in flies.
    1. Cell Biology

    Aging: A new answer to old questions

    Yves Barral
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    1. Evolutionary Biology
    2. Genetics and Genomics

    Reproduction: How flies turn food into progeny

    Thomas Flatt
    Sex-optimal diets have different effects on gene expression in female and male flies.
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    1. Evolutionary Biology
    2. Genetics and Genomics

    The Natural History of Model Organisms: The untapped potential of medaka and its wild relatives

    Leon Hilgers, Julia Schwarzer
    Studies of medaka and other ricefishes in the wild could provide insights in fields such as evolutionary biology, development and cancer research.
    1. Cell Biology
    2. Neuroscience

    The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors

    Heather S Comstra et al.
    The ATP7A interactome is the first comprehensive view of putative Menkes disease neurodegeneration mechanisms.
    1. Human Biology and Medicine

    Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice

    Shunxing Rong et al.
    SREBP-2 directly regulates genes involved in cholesterol homeostasis and indirectly regulates fatty acid synthesis through the production of a ligand responsible for the activation of LXR and SREBP-1c.
    1. Structural Biology and Molecular Biophysics
    2. Human Biology and Medicine

    Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival

    Vladimir Chubanov et al.
    Mice deficient in the TRPM6 channel suffer from impaired prenatal development, shortened lifespan, growth deficit and disturbed energy balance due to a defect in epithelial Mg2+ uptake, thus highlighting a pivotal role of TRPM6 in organismal Mg2+ homeostasis.

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