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    1. Neuroscience

    A conserved code for anatomy: Neurons throughout the brain embed robust signatures of their anatomical location into spike trains

    Gemechu B Tolossa, Aidan M Schneider ... Keith B Hengen
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Plant Biology

    RPG acts as a central determinant for infectosome formation and cellular polarization during intracellular rhizobial infections

    Beatrice Lace, Chao Su ... Thomas Ott
    Infectosomes enabling polar progression of infection threads in legume roots require the symbioisis-related RPG protein that functions as an organizer of these structures.
    1. Neuroscience

    Task-dependent recurrent dynamics in visual cortex

    Satohiro Tajima, Kowa Koida ... Hidehiko Komatsu
    A decoding-based, state-space reconstruction reveals that neurons in macaque IT cortex change the structure of their collective attractor dynamics depending on task contexts.
    1. Evolutionary Biology

    Upstream open reading frames buffer translational variability during Drosophila evolution and development

    Yuanqiang Sun, Yuange Duan ... Jian Lu
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Physics of Living Systems

    Glycan processing in the Golgi as optimal information coding that constrains cisternal number and enzyme specificity

    Alkesh Yadav, Quentin Vagne ... Madan Rao
    A mathematical model of glycosylation in the Golgi apparatus to investigate how the fidelity of synthesising a complex glycan distribution at the plasma membrane depends on parameters such as the number of Golgi cisternae or enzyme specificity.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Quantitative control of noise in mammalian gene expression by dynamic histone regulation

    Deng Tan, Rui Chen ... Wei Huang
    Ubiquitous transcriptional factor-CBP/p300 interaction induces epigenetic and transcriptional bimodality, which can be utilized to tune mean gene expression and noise independently.
    1. Genetics and Genomics

    Age and diet shape the genetic architecture of body weight in diversity outbred mice

    Kevin M Wright, Andrew G Deighan ... Anil Raj
    Genetic effects on body weight in mice are highly heterogeneous, dynamic, and nonlinear with respect to genomic background, age, and diet.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Stochastic tuning of gene expression enables cellular adaptation in the absence of pre-existing regulatory circuitry

    Lydia Freddolino, Jamie Yang ... Saeed Tavazoie
    Stochastic tuning of gene expression could be a common mechanism through which eukaryotic cells adapt to challenging external environments, potentially including survival of infectious organisms within the host and adaptation of cancer cells to chemotherapy.
    1. Developmental Biology
    2. Genetics and Genomics

    Female-biased upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity

    Jason W Millington, George P Brownrigg ... Elizabeth J Rideout
    The ability to adjust body size in response to diet is greater in Drosophila females than males because of a sex difference in the nutrient-dependent regulation of the insulin pathway.
    1. Chromosomes and Gene Expression

    SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A

    Anna M Scarborough, Juliana N Flaherty ... Nicholas K Conrad
    The 3'-end formation complex CFIm regulates S-adenosylmethionine (SAM) homeostasis by promoting the splicing of the SAM synthetase transcript, MAT2A.