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Immunology and Inflammation
Small molecule inhibition of Csk alters affinity recognition by T cells
Boryana N Manz et al.
The T cell response, especially to weak agonists, is enhanced by acute Csk inhibition.
Genetics and Genomics
Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation
Callison E Alcott et al.
Partial reduction of CFIm25 protein levels leads to misregulated alternative polyadenylation in neurons and learning deficits.
Media coverage: September roundup of eLife papers in the news
High-profile news coverage that eLife papers generated in September 2017, including the Independent, Nature and New Scientist.
eLife recognises early-career researchers; Academic editors showcase five outstanding studies
The eLife-sponsored presentation series
Early-career researcher travel grants 2018: First seven authors selected
The eLife travel grant programme offers up to $1000 to help recipients gain exposure and recognition for their work.
PeerTax: Investigating the taxonomy of peer reviews
We describe a machine learning approach towards understanding the fundamental components of peer-review reports.
Adrenergic activation modulates the signal from the Reissner fiber to cerebrospinal fluid-contacting neurons during development
Yasmine Cantaut-Belarif et al.
The Reissner fiber in the cerebrospinal fluid is required for a signal integrated by developing sensory neurons and modulated by catecholamines to control the embryo posterior axis morphogenesis.
Stem Cells and Regenerative Medicine
mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex
Madeline G Andrews et al.
mTOR signaling regulates the morphology of a human-enriched neural stem cell population and thus contributes to the radial architecture of the developing human cortex with implications for neurodevelopmental disease.
Physics of Living Systems
Diffusion vs. direct transport in the precision of morphogen readout
Sean Fancher, Andrew Mugler
A theory predicts whether diffusion or direct transport establishes a more precise morphogen profile, and this prediction explains data from a wide variety of morphogens in two different organisms.
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