729 results found
    1. Cell Biology
    2. Neuroscience

    TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis

    Zhong-Jiao Jiang et al.
    Electrophysiological and live-cell imaging analyses identify a presynaptic function of Ca2+ influx via transient receptor potential melastatin 7 (TRPM7) channels.
    1. Ecology
    2. Evolutionary Biology

    Social-like responses are inducible in asocial Mexican cavefish despite the exhibition of strong repetitive behavior

    Motoko Iwashita, Masato Yoshizawa
    A new tracking method revealed the social-like interactions in the Mexican blind cavefish, which was thought to be evolutionarily lost, and also demonstrated its mammal-like antagonistic association between the social-like interaction and repetitive behavior.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    3′HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression

    Pamela Himadewi et al.
    The 3'HS1 CTCF binding site directly modulates chromosomal loops to regulate γ-globin expression through the accession of the hereditary persistence of fetal hemoglobin enhancer.
    1. Neuroscience

    Convergent and divergent brain structural and functional abnormalities associated with developmental dyslexia

    Xiaohui Yan et al.
    Convergent structural and functional brain deficits associated with dyslexia were found in left superior temporal gyrus across languages, however, language-specific deficits were also identified.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective

    Mona Seifert et al.
    High-throughput and ultra-stable magnetic tweezers reveal that Remdesivir induces a long-lived backtrack pause upon incorporation by the coronavirus polymerase, and SARS-CoV-2 is able to evade interferon-induced antiviral ddhCTP.
    1. Neuroscience

    Bayesian inference of population prevalence

    Robin AA Ince et al.
    Bayesian estimation of the proportion of the population that would show an effect in an experiment provides a broadly applicable alternative to standard null hypothesis tests on the population mean with several advantages.
    1. Neuroscience

    Temporo-cerebellar connectivity underlies timing constraints in audition

    Anika Stockert et al.
    With unique lesion-informed tractography, left hemisphere temporo-cerebellar structural connectivity has been established, supporting rapid auditory transmission and cortical functional lateralization.
    1. Developmental Biology
    2. Evolutionary Biology

    Gamete expression of TALE class HD genes activates the diploid sporophyte program in Marchantia polymorpha

    Tom Dierschke et al.
    The ancestral mechanism to activate diploid gene expression via homeodomain transcription factors was retained in liverworts, an early diverging land plant lineage, and subsequently co-opted during evolution of the diploid sporophyte body.
    1. Neuroscience

    Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats

    Weisheng Wang et al.
    Activity in the hypothalamic dorsal premammillary nucleus predicts future escape from threat, represents escape velocity, and controls escape velocity via a projection to the brainstem.

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