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    1. Cancer Biology
    2. Cell Biology

    Identification of CD133+ intercellsomes in intercellular communication to offset intracellular signal deficit

    Kota Kaneko, Yan Liang ... Gen-Sheng Feng
    A new type of mRNAs-loaded CD133+ vesicles, named intercellsome, mediate cell-cell communications to compensate intracellular proliferative signal deficit, representing a previously unrecognized mechanism of cell proliferation under stress.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome

    Emma A Morrison, Samuel Bowerman ... Catherine A Musselman
    The BPTF PHD finger is inhibited from binding the methylated H3 tails in the context of the nucleosome due to their robust interaction with the nucleosomal DNA, which can be modulated by additional histone PTMs.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Evolution and regulation of microbial secondary metabolism

    Guillem Santamaria, Chen Liao ... Joao B Xavier
    Strains of the bacterium Pseudomonas aeruginosa that use secondary metabolism to make surfactants and change the surface tension of the liquid that surrounds them do so only if they can first meet their primary metabolic needs.
    1. Developmental Biology

    Image3C, a multimodal image-based and label-independent integrative method for single-cell analysis

    Alice Accorsi, Andrew C Box ... Nicolas Rohner
    Image3C is a new image-based analysis of cell population composition for research organisms in which detailed cellular phenotypes are unknown or for which species-specific reagents are not available.
    1. Neuroscience

    Different types of theta rhythmicity are induced by social and fearful stimuli in a network associated with social memory

    Alex Tendler, Shlomo Wagner
    Variations in the frequency of theta brain waves enable a single network of brain regions to generate appropriate responses to stimuli with different kinds of emotional value.
    1. Neuroscience

    The heritability of multi-modal connectivity in human brain activity

    Giles L Colclough, Stephen M Smith ... Mark W Woolrich
    Genes play an important role in determining the strength of functional connectivity in the human brain, and seem to outweigh the contribution from the developmental environment.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Reverse evolution leads to genotypic incompatibility despite functional and active site convergence

    Miriam Kaltenbach, Colin J Jackson ... Nobuhiko Tokuriki
    Enzyme evolution is reversible on a structural and functional (phenotypic) level, but through a different mutational pathway that leads to genotypic incompatibility with the ancestor.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    The Drosophila hematopoietic niche assembles through collective cell migration controlled by neighbor tissues and Slit-Robo signaling

    Kara A Nelson, Kari F Lenhart ... Stephen DiNardo
    A new example of niche formation, revealing the mode of niche cell migration, implicates extrinsic sources of positional information, and uncovers the pathway required for stereotypical positioning of the niche.
    1. Developmental Biology
    2. Genetics and Genomics

    Systematic imaging reveals features and changing localization of mRNAs in Drosophila development

    Helena Jambor, Vineeth Surendranath ... Pavel Tomancak
    Genome wide analysis reveals that many transcripts are localized in cells of the ovary and that the localization status of mRNAs changes over time and in different cell types.
    1. Cell Biology

    TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium

    Karen Baker, Irene A Gyamfi ... Daniel P Mulvihill
    IQ domain phosphorylation regulates calmodulin binding and myosin-1 function.