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CUT&RUN (Cleavage Under Targets & Release Using Nuclease) profiles antibody-targeted DNA-binding proteins in situ with high resolution and low background, providing a simple, robust and scalable alternative to chromatin immunoprecipitation.

The readiness potential—a long-established neural precursor of voluntary action claimed to precede the onset of the conscious decision to move—is absent, or at least significantly reduced, for deliberate decisions.

Lattice light-sheet single-molecule imaging shows 3D Sox2 enhancer clusters in live embryonic stem cells and reveals a model linking 3D spatial distribution of cis-elements, differential target search features and localized gene regulation.

Phylogenetic analyses demonstrate an evolutionary trade-off between the amount of harm inflicted by a broad host-range virus and how effectively the virus positions itself within plants to enable onward transmission.

Sophisticated decision-making mechanisms and complex experimental paradigms can be modeled, simulated, and fit to empirical response time data, using a flexible and efficient computational modeling framework.

Cerebellar functional regions follow a gradual organization, which progresses from primary (motor) to transmodal (Default Mode Network) regions, and a secondary axis extends from task-unfocused to task-focused processing.

Graph genotyping of structural variation in diverse human populations reveals functional associations and signatures of local adaptation within poorly resolved regions of the genome.

Wnt3 accomplishes long-range distribution by extracellular diffusion controlled by expression, tissue morphology, interactions with heparan sulfate proteoglycans, and co-receptor-mediated receptor binding to regulate brain development in zebrafish embryos.

Individual olfactory-driven behaviors, odor preferences, and olfactory sensitivity have rapidly evolved in blind Mexican cavefish, as a quantitative genetic trait.