3,074 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    High-quality carnivoran genomes from roadkill samples enable comparative species delineation in aardwolf and bat-eared fox

    Rémi Allio, Marie-Ka Tilak ... Frédéric Delsuc
    High-quality genomes can be obtained from roadkill samples and used in population genomics for species delimitation with conservation implications.
    1. Cell Biology
    2. Genetics and Genomics

    Novel regulators of islet function identified from genetic variation in mouse islet Ca2+ oscillations

    Christopher H Emfinger, Lauren E Clark ... Alan D Attie
    Analysis of islet calcium oscillation responses will provide the field with a resource with which to determine the strain of interest for their specific islet biology questions.
    1. Ecology
    2. Microbiology and Infectious Disease

    A diverse host thrombospondin-type-1 repeat protein repertoire promotes symbiont colonization during establishment of cnidarian-dinoflagellate symbiosis

    Emilie-Fleur Neubauer, Angela Z Poole ... Virginia M Weis
    The colonization of corals and their relatives by intracellular microalgae is facilitated by immunity proteins in the animal that contain thrombospondin-type-1 repeats, elucidating the inter-partner recognition processes required for the establishment of this ecologically important symbiosis.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Regulatory genome annotation of 33 insect species

    Hasiba Asma, Ellen Tieke ... Marc S Halfon
    Over 2.8 million tissue-specific gene regulatory sequences are predicted for 33 insect genomes, using a simple computational workflow with only the genome sequence and a basic gene annotation as input.
    1. Evolutionary Biology

    The skin microbiome facilitates adaptive tetrodotoxin production in poisonous newts

    Patric M Vaelli, Kevin R Theis ... Heather L Eisthen
    Skin-associated bacteria underlie the production of a potent defensive neurotoxin in newts, impacting host physiology, molecular evolution, and predator-prey interactions in a coevolutionary arms race.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

    Qin Li, Sika Zheng ... Douglas L Black
    PTBP2 ensures that adult protein variants are expressed only in mature neurons through regulation of alternative splicing during early neuronal development.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Effect of α-tubulin acetylation on the doublet microtubule structure

    Shun Kai Yang, Shintaroh Kubo ... Khanh Huy Bui
    Cryo-EM studies of doublet microtubules from wild-type and acetylation mutants suggest that acetylation of K40 affects the lateral rotational angle between protofilaments, leading to changes in the structure and stability.
    1. Developmental Biology
    2. Evolutionary Biology

    Gene age shapes the transcriptional landscape of sexual morphogenesis in mushroom-forming fungi (Agaricomycetes)

    Zsolt Merényi, Máté Virágh ... László G Nagy
    Allele-specific expression, natural antisense transcripts, and developmental gene expression, but not RNA editing or developmental hourglass, act in concert to shape the transcriptome during the fruiting body formation of complex multicellular fungi.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells

    Hamish W King, Robert J Klose
    The chromatin remodeller BRG1 is recruited to pluripotency-associated gene regulatory elements by the pioneer transcription factor OCT4 to support further transcription factor binding and gene regulation.
    1. Cancer Biology
    2. Ecology

    Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe

    Daniel Garcia-Souto, Alicia L Bruzos ... Jose MC Tubio
    Genome sequencing analysis dissects the origins and evolution of cancer transmission between clam species in the Seas of Southern Europe.

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