24 results found
    1. Immunology and Inflammation

    A novel role for lipoxin A4 in driving a lymph node–eye axis that controls autoimmunity to the neuroretina

    Jessica Wei et al.
    LXA4 in lymph nodes is an important resident homeostatic regulator that controls effector T cell functions and egress in the development of adaptive immune responses.
    1. Microbiology and Infectious Disease

    Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins

    Nitzan Koppel et al.
    A unique, widely distributed gut bacterial enzyme selectively metabolizes plant-derived cardiac glycoside drugs.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression

    Tonya Kueck et al.
    Distinct antiviral signaling pathways, triggered by the aryl hydrocarbon receptor and Interferon-gamma, converge on CDK/cyclin repression, causing inhibition of viral DNA synthesis.
    1. Ecology

    A moth odorant receptor highly expressed in the ovipositor is involved in detecting host-plant volatiles

    Rui-Ting Li et al.
    A moth can detect plant volatiles using an odorant receptor expressing in its ovipositor, and this odorant receptor has a much higher expression level in the ovipositor than antennae.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols

    Vayu Maini Rekdal et al.
    A previously unrecognized group of metalloenzymes enables human gut microbes to metabolize dietary molecules and neurotransmitters and likely mediates interactions and metabolism among environmental microorganisms.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    The human gut chemical landscape predicts microbe-mediated biotransformation of foods and drugs

    Leah Guthrie et al.
    A network of the gut chemical landscape predicts microbe-mediated biotransformation of foods and drugs and supports the generation of mechanistic hypotheses of microbiome metabolic phenotypes that shape human biology.
    1. Cell Biology
    2. Developmental Biology

    miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6

    Eleonora Franzoni et al.
    The regulation of Phf6 by miR-128 is a developmental timing mechanism that influences cortical lamination, neuronal morphology and intrinsic excitability.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A general strategy to construct small molecule biosensors in eukaryotes

    Justin Feng et al.
    A new method for developing biosensors from ligand binding domains that have concentration-dependent and selective responses to small molecules in yeast, mammalian cells and plants.
    1. Microbiology and Infectious Disease

    Bidirectional interactions between indomethacin and the murine intestinal microbiota

    Xue Liang et al.
    Indomethacin, a nonsteroidal anti-inflammatory drug, alters the composition of the intestinal microbiota, and the intestinal microbiota affect the pharmacokinetics of indomethacin.
    1. Cancer Biology

    BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

    Nicolas Bery et al.
    A biosensor resource has been developed to monitor the intracellular interactions of RAS family proteins with effector molecules and the effects of inhibitors as an aid to drug development.

Refine your results by:

Type
Research categories