540 results found
    1. Developmental Biology
    2. Plant Biology

    Temporal integration of auxin information for the regulation of patterning

    Carlos S Galvan-Ampudia, Guillaume Cerutti ... Teva Vernoux
    Rhythmic centrifugal waves of auxin traveling through the tissue provides high definition positional information to cells that is not only spatial but also temporal.
    1. Cell Biology
    2. Physics of Living Systems

    Interplay of cell dynamics and epithelial tension during morphogenesis of the Drosophila pupal wing

    Raphaël Etournay, Marko Popović ... Suzanne Eaton
    Autonomous patterns of cell contraction in the context of localized apical extracellular matrix constraints specify tissue stresses that reshape the wing epithelium.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    SWI/SNF senses carbon starvation with a pH-sensitive low-complexity sequence

    J Ignacio Gutierrez, Gregory P Brittingham ... Liam J Holt
    A combination of single-cell analysis, genomics, and simulations shows that a glutamine-rich low-complexity sequence in the SWI/SNF chromatin remodeling complex senses transient intracellular acidification as a signal for cells to switch their global transcriptional program.
    1. Evolutionary Biology
    2. Stem Cells and Regenerative Medicine

    A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice

    Michael J Abrams, Fayth Hui Tan ... Lea Goentoro
    Amino acid and sugar supplement induce appendage/limb regeneration in cnidarians, insects, and mammals.
    1. Developmental Biology
    2. Genetics and Genomics

    Paths and pathways that generate cell-type heterogeneity and developmental progression in hematopoiesis

    Juliet R Girard, Lauren M Goins ... Utpal Banerjee
    A combination of mRNA sequencing and genetic analysis reveals mechanisms that govern the development of distinct differentiated blood cell types from hematopoietic progenitors.
    1. Physics of Living Systems

    Epithelial-to-mesenchymal transition proceeds through directional destabilization of multidimensional attractor

    Weikang Wang, Dante Poe ... Jianhua Xing
    Integrated live cell imaging and image analyses in the framework of transition path theories identify epithelial-to-mesenchymal transition proceeds through parallel paths.
    1. Computational and Systems Biology
    2. Plant Biology

    A coupled mechano-biochemical model for cell polarity guided anisotropic root growth

    Marco Marconi, Marcal Gallemi ... Krzysztof Wabnik
    The spatial-temporal computer model of plant root meristem combines biomechanics and biochemical scales to reveal design principles underlying cell polarity and anisotropic growth during root development.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration

    Konstantinos Sousounis, Donald M Bryant ... Jessica L Whited
    Experimental manipulation of a core DNA damage response factor and cell-cycle checkpoint regulators reveals a key role for these processes in the progenitor cells that fuel limb regeneration.
    1. Epidemiology and Global Health

    Antigenic strain diversity predicts different biogeographic patterns of maintenance and decline of antimalarial drug resistance

    Qixin He, John K Chaillet, Frédéric Labbé
    A novel compartment model identifies the impact of malaria strain diversity on biogeographic drug resistance patterns, supported by empirical evidence.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Single mosquito metatranscriptomics identifies vectors, emerging pathogens and reservoirs in one assay

    Joshua Batson, Gytis Dudas ... Hanna Retallack
    How large-scale single mosquito metatranscriptomics can define the mosquito’s complex microbiota and its blood meal sources, and contribute critical epidemiological information needed to control vector borne disease transmission, is shown.

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