767 results found
    1. Medicine

    Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome

    Simone Bersini et al.
    Direct reprogramming of smooth muscle cells from HGPS patients revealed that BMP4 is a key contributor of vascular degeneration and might represent a new therapeutic target.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons

    Chongyuan Luo et al.
    Induced neuronal cells acquire epigenomic signatures specific to matured neurons.
    1. Stem Cells and Regenerative Medicine

    Mouse embryonic stem cells can differentiate via multiple paths to the same state

    James Alexander Briggs et al.
    Single cell RNA sequencing reveals that mouse embryonic stem cells can be differentiated into the same terminal motor neuron state via distinct differentiation paths, one of which includes a surprising intermediate state not found in embryos.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Generation of inner ear hair cells by direct lineage conversion of primary somatic cells

    Louise Menendez et al.
    Direct reprogramming of somatic cells to an inner ear sensory hair cell-like state provides an experimental platform to identify causes and treatments for hair cell loss and hearing deficits.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells

    Marius Walter et al.
    The various transposon families of the mammalian genome can adopt different types of repressive chromatin responses upon DNA methylation loss.
    1. Plant Biology

    Auxin-regulated chromatin switch directs acquisition of flower primordium founder fate

    Miin-Feng Wu et al.
    SWI/SNF chromatin remodeling complexes act as ‘gatekeepers’ for auxin responses and directly interact with the auxin response factor MONOPTEROS.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Aurkb/PP1-mediated resetting of Oct4 during the cell cycle determines the identity of embryonic stem cells

    Jihoon Shin et al.
    The regulation of the core transcription factor Oct4 by the Aurkb-PP1 axis links the cell cycle to pluripotency programs in embryonic stem cells.
    1. Neuroscience

    Brian 2, an intuitive and efficient neural simulator

    Marcel Stimberg et al.
    Brian 2 is a software package for neural simulations that makes it both easy and computationally efficient to define original models for computational experiment.
    1. Stem Cells and Regenerative Medicine

    In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes

    Weida Li et al.
    Combinations of transcription factors can convert pancreatic acinar cells into endocrine α-, β- and δ-cells in vivo.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability

    Judith Schütte et al.
    A computer model built on insights gained from comprehensive experimental analysis reveals mechanisms of blood stem cell regulation.

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