Epigenomic and transcriptomic analysis reveals that paternal obesity influences sperm histone H3 lysine 4 tri-methylation enrichment and placenta gene expression, which in turn negatively impact its development and function in a manner that may contribute to metabolic disease in offspring.

A new example of niche formation, revealing the mode of niche cell migration, implicates extrinsic sources of positional information, and uncovers the pathway required for stereotypical positioning of the niche.

Titin’s regulated integration and mobility after cell fusion support syncytium formation in culture, while limited diffusion in vivo highlights a key challenge for developing effective cell-based therapies for skeletal muscle diseases.

Marcks and Marcks-like 1 proteins are required for normal neurite formation and proliferation of neuro-glial progenitors during development and regeneration of the Xenopus spinal cord implicating these proteins as critical new factors for spinal cord development and regeneration.