2,012 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo

    Megan L Martik, David R McClay
    The gene regulatory network controlling directed cell migration in a sea urchin is strikingly similar to a sub-circuit for eye development in Drosophila, suggesting that ancient systems-level controls may be adapted for diverse functions in different animals.
    1. Developmental Biology

    Dynamic filopodia are required for chemokine-dependent intracellular polarization during guided cell migration in vivo

    Dana Meyen, Katsiaryna Tarbashevich ... Erez Raz
    Functional analysis of filopodia by specific interference with their formation and distribution reveals a critical role in conferring intracellular polarity and in controlling the dynamic properties of chemokine-guided cell migration in vivo.
    1. Developmental Biology
    2. Neuroscience

    Correct setup of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons

    Ankita Ravi Vaswani, Beatrice Weykopf ... Sandra Blaess
    The first comprehensive insight into speed, trajectory and morphology profiles of tangentially migrating dopaminergic neurons and the alterations in their migratory behavior in absence of Reelin signaling.
    1. Cell Biology
    2. Developmental Biology

    Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration

    Daniel Čapek, Michael Smutny ... Carl-Philipp Heisenberg
    Uniform activation of Frizzled7 signaling is required and sufficient for directional mesendoderm cell migration during zebrafish gastrulation.
    1. Cell Biology
    2. Physics of Living Systems

    Persistent cell migration emerges from a coupling between protrusion dynamics and polarized trafficking

    Kotryna Vaidžiulytė, Anne-Sophie Macé ... Mathieu Coppey
    Quantitative proof that persistent cell migration in the timescale of hours relies on a feedback between polarized trafficking and protrusive activity stabilizing cell front.
    1. Cell Biology
    2. Developmental Biology

    Single-cell transcriptome analysis of avian neural crest migration reveals signatures of invasion and molecular transitions

    Jason A Morrison, Rebecca McLennan ... Paul M Kulesa
    Single cell transcriptome analysis of an embryonic collective migratory cell population provides new insights into the heterogeneity of transcriptional signatures within a neural crest cell migratory stream.
    1. Physics of Living Systems

    3D single cell migration driven by temporal correlation between oscillating force dipoles

    Amélie Luise Godeau, Marco Leoni ... Daniel Riveline
    A phase shift between local contractions drives 3D cell motility in experiments and in model or how a finite area in the dipole-quadrupole space explains cell motion with zero total force.
    1. Developmental Biology

    Ongoing repair of migration-coupled DNA damage allows planarian adult stem cells to reach wound sites

    Sounak Sahu, Divya Sridhar ... Aziz Aboobaker
    Adult stem cells acquire increased DNA damage as they migrate to a wound site and require active DNA repair mechanisms for normal migration.
  1. Eph and Ephrin function in dispersal and epithelial insertion of pigmented immunocytes in sea urchin embryos

    Oliver A Krupke, Ivona Zysk ... Robert D Burke
    Eph receptor signaling commonly excludes migrating embryonic cells from regions of high ligand density; however, in sea urchin embryos pigmented immunocytes are attracted to regions expressing high levels of Ephrin.
    1. Developmental Biology

    The myocardium utilizes a platelet-derived growth factor receptor alpha (Pdgfra)–phosphoinositide 3-kinase (PI3K) signaling cascade to steer toward the midline during zebrafish heart tube formation

    Rabina Shrestha, Tess McCann ... Joshua Bloomekatz
    Research on heart tube assembly using zebrafish reveals a pivotal role for intrinsic Pdgfra–PI3K signaling in steering the movement of the myocardium and polarizing myocardial cell protrusions.

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