Disconnection of the orbitofrontal cortex from the submedius nucleus but not the mediodorsal thalamus prevented rats to respond adaptively following action-outcome reversal, showing differential involvement of these thalamocortical circuits.
Electrophysiology pinpoints brain function abnormalities in young people genetically at risk of developing Alzheimer's disease much later in life, supporting theories of initial hyperconnectivity driving eventual profound disconnection.
A hub in the rostral anterior cingulate cortex receives unusually high and functionally diverse inputs, providing a biological interface between motivation, incentive based learning, and decision making.
Proteolysis of lipidated N-terminal peptides that tether Hedgehog morphogens to the surface of source cells is absolutely required for their coupled release and bioactivation in vivo in Drosophila melanogaster.
An innovative inter-subject stimulus-locked brain activation approach uncovers marked topological differences in a brain network of higher-order visual regions in individuals with a congenital impairment in face recognition compared with controls.
LRRK2 G2019S knock-in mice are a genetically faithful model that recapitulates the slow disease progression of familial PD, with initial alterations to behaviour and neurotransmission providing early pathophysiological targets for neuroprotective interventions.