HLA class I-disease associations have been studied for decades; a new approach for investigating the underlying mechanism can overcome past problems with interpretation and help to understand the etiology of human diseases.
Standing genetic variation for disease resistance may be continuously lost during recurring warm water episodes because of widespread susceptibility of disease-resistant genotypes to bleaching and the independence between these two traits.
Identification of causal genes and their effects on other biological determinants untangles the complexities of aging and Alzheimer's and can facilitate drug discovery for sustaining healthy aging and treating Alzheimer's.
An integrated stem cell-based disease modeling and computational approach demonstrates how proximal airway epithelium is critical for SARS-CoV-2 infectivity and distal alveolar cells are critical for simulating the host responses.
Analyses of detailed clinical and entomological data from cohort studies reveal how anti-parasite and anti-disease immunity against P. falciparum develop as a function of age and transmission intensity.