5,530 results found
    1. Computational and Systems Biology
    2. Developmental Biology

    A human ESC-based screen identifies a role for the translated lncRNA LINC00261 in pancreatic endocrine differentiation

    Bjoern Gaertner et al.
    Ribosome profiling and loss-of-function during human ESC pancreatic differentiation reveal abundant lncRNA translation and an essential role for translated LINC00261 in beta cell differentiation, likely through a trans-regulatory, microprotein-independent mechanism.
    1. Developmental Biology
    2. Medicine

    RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1

    Md Rakibul Hasan et al.
    RAB23 regulates calvarial bone and suture development both independently through, and by cross-talk between, Hedgehog and fibroblast growth factor signaling.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    An analog to digital converter controls bistable transfer competence development of a widespread bacterial integrative and conjugative element

    Nicolas Carraro et al.
    A new multistep hierarchical cascade controls activation of an integrative and conjugative element in a small subpopulation of cells in its bacterial host, yielding proficient DNA transferring cells.
  1. Research Culture: Changing how we evaluate research is difficult, but not impossible

    Anna Hatch, Stephen Curry
    The DORA initiative offers practical guidance on improving the assessment of research by universities, research institutions, and funders.
    1. Structural Biology and Molecular Biophysics

    Structure and mechanism of the Mrp complex, an ancient cation/proton antiporter

    Julia Steiner, Leonid Sazanov
    Structure of the Mrp antiporter, an ancestor of respiratory complex I, suggests a mechanism of coupling between cation and proton translocation, applicable to a large family of related membrane proteins.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Modeling the metabolic interplay between a parasitic worm and its bacterial endosymbiont allows the identification of novel drug targets

    David M Curran et al.
    A genome scale model of Brugia malayi metabolism illustrates a dynamic reliance on energy production pathways across its life cycle and identifies new drugs with experimentally supported anti-parasitic properties.
    1. Ecology
    2. Evolutionary Biology

    Caterpillar-induced rice volatiles provide enemy-free space for the offspring of the brown planthopper

    Xiaoyun Hu et al.
    The brown planthopper has evolved a highly adaptive oviposition strategy by exploiting caterpillar-induced plant volatiles that provide safe havens for its offspring.
    1. Microbiology and Infectious Disease

    MARCH8 inhibits viral infection by two different mechanisms

    Yanzhao Zhang et al.
    The host transmembrane protein MARCH8, previously known as an expression regulator of host proteins, is a powerful antiviral host factor with a potentially broad antiviral spectrum through two different mechanisms.
    1. Medicine

    Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes

    Mi Lai et al.
    Lipid dysmetabolism occurs at postpartum in women who progress from GDM to type 2 diabetes, and specific lipids could predict the progression.

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