Browse the search results

Page 2 of 439
    1. Neuroscience

    Animal Models of Disease: Fly model causes neurological rethink

    Madhumala K Sadanandappa, Mani Ramaswami
    Insight
    Available as:
    • HTML
    • PDF
    1. Neuroscience

    Diverse modes of synaptic signaling, regulation, and plasticity distinguish two classes of C. elegans glutamatergic neurons

    Donovan Ventimiglia, Cornelia I Bargmann
    Single-neuron synaptic imaging in vivo demonstrates that highly conserved molecules such as UNC-13, UNC-18, and protein kinase C, which are found at essentially every synapse make different functional contributions in Caenorhabditis elegans glutamatergic neurons.
    1. Human Biology and Medicine
    2. Neuroscience

    Tissue Engineering: Building a better blood-brain barrier

    Courtney Lane-Donovan, Joachim Herz
    A new three-dimensional model of the blood-brain barrier can be used to study processes that are involved in neurodegenerative diseases.
    Insight
    Available as:
    • HTML
    • PDF
    1. Neuroscience

    Loss of presenilin function is associated with a selective gain of APP function

    Carole Deyts et al.
    Amyloid precursor protein expression and accumulation of its intracellular fragment are required for exuberant neurite outgrowth associated with pathological presenilin 1 loss-of-function mutations before the emergence of amyloid burden in mice.
    1. Microbiology and Infectious Disease
    2. Ecology

    The Natural History of Model Organisms: The unexhausted potential of E. coli

    Zachary D Blount
    A better understanding of the remarkable diversity, natural history and complex ecology of E. coli in the wild could shed new light on its biology and role in disease, and further expand its many uses as a model organism.
    1. Epidemiology and Global Health

    A user-friendly, open-source tool to project impact and cost of diagnostic tests for tuberculosis

    David W Dowdy et al.
    A freely available computer program that takes into account specific local conditions enables users to predict the impact of adopting different diagnostic strategies on the spread of tuberculosis in their region.
    1. Human Biology and Medicine
    2. Neuroscience

    Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment

    Cemre Celen et al.
    Mirroring human patients with ARID1B mutations, Arid1b haploinsufficient mice exhibited numerous neuropsychiatric defects and revealed IGF1 deficiency related growth impairment that could be ameliorated with growth hormone supplementation.
    1. Developmental Biology

    Pilot study of large-scale production of mutant pigs by ENU mutagenesis

    Tang Hai et al.
    ENU mutagenesis in pigs is an efficient strategy to introduce mutations at the whole-genome level and mutants have been generated on a large scale for agricultural production and biomedical research.
    1. Ecology
    2. Epidemiology and Global Health

    Mycobacterium ulcerans dynamics in aquatic ecosystems are driven by a complex interplay of abiotic and biotic factors

    Andrés Garchitorena et al.
    Different transmission routes of Mycobacterium ulcerans to aquatic organisms may prevail depending on local physico-chemical conditions.
    1. Computational and Systems Biology

    Evolutionary dynamics of incubation periods

    Bertrand Ottino-Loffler et al.
    Evolutionary graph theory solves the longstanding puzzle of why diverse infectious diseases and cancers show similar (approximately lognormal) distributions of their incubation periods.