3,377 results found
    1. Ecology

    Bleaching causes loss of disease resistance within the threatened coral species Acropora cervicornis

    Erinn M Muller et al.
    Standing genetic variation for disease resistance may be continuously lost during recurring warm water episodes because of widespread susceptibility of disease-resistant genotypes to bleaching and the independence between these two traits.
    1. Microbiology and Infectious Disease

    Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure

    Fernando J Sánchez-Valdéz et al.
    Intracellular amastigotes of the Chagas disease agent Trypanosoma cruzi can spontaneously enter an extended state of replicative dormancy, during which time they are resistant to drug treatment both in vitro and in vivo.
    1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor

    A Maqbool et al.
    Structure/function studies of a plant pathogen effector in complex with a host disease resistance protein domain reveal the molecular basis for recognition and underpin future engineering of immunity in crops.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Protein engineering expands the effector recognition profile of a rice NLR immune receptor

    Juan Carlos De la Concepcion et al.
    Structure-led protein engineering can expand the effector recognition profile of plant intracellular NLR immune receptors, providing a proof-of-principle for the development of novel disease resistance mechanisms in plants.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Long-term balancing selection drives evolution of immunity genes in Capsella

    Daniel Koenig et al.
    Retention of genetic diversity at immune-related loci drives the pattern of genetic variation in selfing Capsella.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome plasticity in Candida albicans is driven by long repeat sequences

    Robert T Todd et al.
    Previously uncharacterized long repeat sequences are associated with significant genome variation that can increase fitness and promote antifungal drug resistance in diverse isolates of Candida albicans.
    1. Plant Biology

    Identification and characterisation of hypomethylated DNA loci controlling quantitative resistance in Arabidopsis

    Leonardo Furci et al.
    Analysis of epigenetic recombinant inbred lines of Arabidopsis identified four hypomethylated DNA loci controlling quantitative disease resistance, which is associated with genome-wide priming of defence genes without affecting plant growth.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Bacterial Evolution: The road to resistance

    Devon M Fitzgerald
    The way that bacteria grow—either floating in liquid or attached to a surface—affects their ability to evolve antimicrobial resistance and our ability to treat infections.
    Insight
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