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HIV-1 infection activates the human CARD8 inflammasome via innate immune recognition of HIV-1 viral protease activity.

Bats' uniquely robust innate antiviral immune defenses select for faster transmitting viruses likely to generate extreme virulence upon spillover to secondary hosts with immune systems divergent from those of bat.

Previous studies and emerging data on pseudohypoxic diseases suggest that the complex phenotypic spectrum of VHL disease is due to the extent of HIF pathway deregulation in susceptible cell types and not by other purported substrates or functions of pVHL.

Tick-derived sequence variation in the fusion glycoprotein of Crimean-Congo hemorrhagic fever virus (CCHFV) drastically impairs infection of mammalian cells, suggesting that certain CCHFV strains undergo purifying selection in mammalian hosts.

Adding a One Health approach to a research framework for minority health and health disparities encourages the exploration of new avenues of inquiry, multidisciplinary collaboration, and the consideration of new determinants of health.

Mineralized placental tissue from Late Byzantine Troy enables the detailed reconstruction of genomes of mixed bacterial species responsible for maternal sepsis in the ancient world.

Yellow fever, a potentially deadly viral hemorrhagic fever, causes up to 82,000 deaths annually worldwide, and mass vaccination activities have reduced the burden by 47% in Africa.

ImmunoCluster permits nonspecialist users to interrogate liquid and imaging mass, and flow cytometry datasets, resolving novel layers of cellular heterogeneity and insight, as well as producing publishable outputs and figures.

Several different mutations in the SARS-CoV-2 genome have occurred more times than expected by chance in either mink or deer infections, suggesting species-specific viral adaptations to these animals.