928 results found
    1. Neuroscience

    Non-linear dimensionality reduction on extracellular waveforms reveals cell type diversity in premotor cortex

    Eric Kenji Lee, Hymavathy Balasubramanian ... Chandramouli Chandrasekaran
    WaveMAP is a novel approach that combines nonlinear dimensionality reduction with graph clustering on extracellular waveforms to reveal previously obscured cell type diversity in monkey cortex.
    1. Structural Biology and Molecular Biophysics

    Three-dimensional flagella structures from animals’ closest unicellular relatives, the Choanoflagellates

    Justine M Pinskey, Adhya Lagisetty ... Daniela Nicastro
    Cryo-electron microscopy reveals previously undescribed structural features of choanoflagellate flagella and provides new insights into flagellar evolution.
    1. Neuroscience

    Selective transduction and photoinhibition of pre-Bötzinger complex neurons that project to the facial nucleus in rats affects nasofacial activity

    Mariana R Melo, Alexander D Wykes ... Andrew M Allen
    The pre-Bötzinger complex, known as the kernel for the breathing generation, consists of separate subpopulations of neurons that project to specific nuclei to coordinate respiratory rhythmicity with different physiological behaviors, such as nasofacial activity.
    1. Neuroscience

    A toolbox of IgG subclass-switched recombinant monoclonal antibodies for enhanced multiplex immunolabeling of brain

    Nicolas P Andrews, Justin X Boeckman ... James S Trimmer
    This paper describes an effective pipeline for conversion of conventional monoclonal antibodies into recombinant form that results in an IgG subclass switch that greatly expands their utility for multiplex labeling.
    1. Neuroscience

    Endocannabinoid dynamics gate spike-timing dependent depression and potentiation

    Yihui Cui, Ilya Prokin ... Hugues Berry
    The molecular mechanisms beyond the bidirectionality (tTLP and tLTD) of endocanabinoid spike-timing dependent synaptic plasticity have been identified.
    1. Neuroscience

    The readily-releasable pool dynamically regulates multivesicular release

    Jada H Vaden, Gokulakrishna Banumurthy ... Jacques I Wadiche
    The number of neurotransmitter vesicles released into the synaptic cleft is regulated by the size of the readily-releasable pool upstream of release probability.
    1. Cell Biology
    2. Computational and Systems Biology

    Spatially coordinated dynamic gene transcription in living pituitary tissue

    Karen Featherstone, Kirsty Hey ... Julian RE Davis
    Quantitative statistical modelling reveals local coordination of stochastic gene transcription dynamics in pituitary tissue, which is relevant for integrated tissue responses to physiological stimuli.
    1. Physics of Living Systems

    Effects of growth feedback on adaptive gene circuits: A dynamical understanding

    Ling-Wei Kong, Wenjia Shi ... Ying-Cheng Lai
    Revised
    Reviewed Preprint v2
    Updated
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    1. Cell Biology
    2. Neuroscience

    Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia

    Lauritz Kennedy, Emilie R Glesaaen ... Johanne E Rinholm
    HCAR1 knockout mice are unable to initiate brain tissue repair after a hypoxic-ischemic injury.
    1. Neuroscience

    EM connectomics reveals axonal target variation in a sequence-generating network

    Jörgen Kornfeld, Sam E Benezra ... Michael A Long
    Combining light microscopy and electron microscopy uncovered patterns of neural connectivity in a zebra finch forebrain region capable of generating song-related sequential activity, contributing to our understanding of the neural circuitry that underlies skilled motor performance.

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