1,392 results found
    1. Cell Biology
    2. Computational and Systems Biology

    Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins

    Tyler S Harmon et al.
    Computational modeling and theoretical analysis reveal how disordered linkers determine whether linear multivalent proteins undergo gelation with or without phase separation.
    1. Epidemiology and Global Health

    Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders

    Jan Sundquist et al.
    A Swedish national cohort study reveals that children with a family history of alcohol use disorders have an increased risk of autism and attention-deficit/hyperactivity disorder.
    1. Biochemistry
    2. Biophysics and Structural Biology

    Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation

    F Donelson Smith et al.
    Structural analysis of an AKAP18-protein kinase A complex reveals that regions of intrinsic disorder impact the phosphorylation of preferred substrates.
    1. Biophysics and Structural Biology

    Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor

    Jing Li et al.
    Allostery in an intrinsically disordered domain of glucocorticoid receptor is mediated by opposing thermodynamic signals that are directed through the production of different isoforms.
    1. Biochemistry
    2. Genes and Chromosomes

    Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation

    Zhengjian Zhang et al.
    An inorganic tin oxochloride cluster specifically binds to an intrinsically disordered, histidine-rich, low complexity protein region and arrests de novo transcription initiation without affecting reinitiation.
    1. Neuroscience

    Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders

    Xiangling Meng et al.
    Excitatory signaling impairment contributes to neurological deficits shared by Rett syndrome and a number of postnatal neuropsychiatric disorders.
    1. Biophysics and Structural Biology
    2. Computational and Systems Biology

    Emergence and evolution of an interaction between intrinsically disordered proteins

    Greta Hultqvist et al.
    The resurrection of ancient ancestral intrinsically disordered proteins reveals the evolution of a protein-protein interaction in molecular detail.
    1. Neuroscience

    MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders

    Adam J Harrington et al.
    Mice that lack the autism- and schizophrenia-linked gene MEF2C in cortical neurons have an imbalance of excitatory and inhibitory synapses, and impaired social and cognitive abilities.
    1. Neuroscience

    A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin β1 subunit, Lamb1

    Yi Bessie Liu et al.
    A mouse with a defined mutation in an extracellular matrix protein that is expressed in selected neurons sheds light on circuit abnormalities producing transient hyperkinetic movements.
    1. Biophysics and Structural Biology
    2. Cell Biology

    Disordered clusters of Bak dimers rupture mitochondria during apoptosis

    Rachel T Uren et al.
    Dimers of Bak assemble into clusters without using a distinct protein-protein interface, which may explain the apparent difficulties in obtaining high resolution structures of the pore complex and in targeting dimer-dimer interactions to regulate apoptosis.

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