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    1. Structural Biology and Molecular Biophysics

    Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments

    Sofia Lövestam, Jane L Wagstaff ... Sjors HW Scheres
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Solid
    1. Neuroscience

    Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    François Kroll, Joshua Donnelly ... Jason Rihel
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    p53 engagement is a hallmark of an unfolded protein response in the nucleus of mammalian cells

    Joseph H Park, Thomas J Wandless
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Neuroscience

    GnRH pulse generator activity in mouse models of polycystic ovary syndrome

    Ziyue Zhou, Su Young Han ... Allan E Herbison
    Common mouse models of polycystic ovary syndrome (PCOS) have variable ability to recapitulate the increased GnRH pulse generator frequency thought to exist in women with PCOS.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Opening and closing of a cryptic pocket in VP35 toggles it between two different RNA-binding modes

    Upasana L Mallimadugula, Matthew A Cruz ... Gregory R Bowman
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with the nuclear speckle

    Chiara Tomasini, Celine Cuche ... Francesca Di Nunzio
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Eco-evolutionary dynamics of adapting pathogens and host immunity

    Pierre Barrat-Charlaix, Richard A Neher
    Diverse histories of viral exposure, for example in individuals of different age, makes viral evolution less predictable with features of adaptive and neutral evolution.
    1. Developmental Biology
    2. Physics of Living Systems

    The geometric basis of epithelial convergent extension

    Fridtjof Brauns, Nikolas H Claussen ... Boris I Shraiman
    Active and passive contributions to cell shape change and rearrangements can be distinguished from observed cell geometry, revealing the self-organization mechanisms underlying internally-driven epithelial convergent extension.
    1. Neuroscience

    High-throughput unsupervised quantification of patterns in the natural behavior of marmosets

    William Menegas, Erin Corbett ... Guoping Feng
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    An integrated machine learning approach delineates an entropic expansion mechanism for the binding of a small molecule to α-synuclein

    Sneha Menon, Subinoy Adhikari, Jagannath Mondal
    Interaction of small molecule expands the conformational ensemble of alpha synuclein.
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