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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The guide sRNA sequence determines the activity level of box C/D RNPs

    Andrea Graziadei, Frank Gabel ... Teresa Carlomagno
    Integrative structural biology reveals a conformational equilibrium in the Box C/D methylation enzyme that regulates the extent of site-specific 2'-O-rRNA methylation in dependence of the RNA sequence.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Spatial correlations constrain cellular lifespan and pattern formation in corneal epithelium homeostasis

    Lior Strinkovsky, Evgeny Havkin ... Yonatan Savir
    Rejuvenation of corneal epithelium in homeostasis is determined by the interplay between corneal cells replicative lifespan and the spatial correlation between cell replication and cell removal.
    1. Developmental Biology
    2. Neuroscience

    Microtubule networks in zebrafish hair cells facilitate presynapse transport and fusion during development

    Saman Hussain, Katherine Pinter ... Katie Kindt
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology

    An amphipathic helix in Brl1 is required for nuclear pore complex biogenesis in S. cerevisiae

    Annemarie Kralt, Matthias Wojtynek ... Karsten Weis
    Genetic, proteomic, and structural analyses provide insight into the role of Brl1 during nuclear pore complex biogenesis, suggesting a function in the fusion of outer and inner nuclear membranes.
    1. Neuroscience

    Sensory cortex is optimized for prediction of future input

    Yosef Singer, Yayoi Teramoto ... Nicol S Harper
    Prediction of future input explains diverse neural tuning properties in sensory cortex.
    1. Cell Biology

    Sphingomyelin metabolism controls the shape and function of the Golgi cisternae

    Felix Campelo, Josse van Galen ... Vivek Malhotra
    Association of curvature generating proteins to the Golgi membranes by sphingomyelin metabolism essentially controls the flatness of a Golgi cisterna that is necessary for efficient sorting and export.
    1. Structural Biology and Molecular Biophysics
    2. Stem Cells and Regenerative Medicine

    ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation

    Nataliya Nady, Ankit Gupta ... Joanna Wysocka
    The Mtgr1 protein promotes the maintenance of pluripotency and germ cell formation via its interaction with the stem cell regulator Prdm14.
    1. Ecology

    Group size and composition influence collective movement in a highly social terrestrial bird

    Danai Papageorgiou, Damien Roger Farine
    High-resolution GPS data revealed a quadratic relationship between group size and movement, with vulturine guineafowl groups of intermediate size exhibiting the largest home-range size and greater variation in site use.
    1. Neuroscience
    2. Physics of Living Systems

    Beta oscillations and waves in motor cortex can be accounted for by the interplay of spatially structured connectivity and fluctuating inputs

    Ling Kang, Jonas Ranft, Vincent Hakim
    The observed activity of the motor cortex in space and time is reproduced by a model with a specific structure of the inputs to the motor cortex.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Ion counting demonstrates a high electrostatic field generated by the nucleosome

    Magdalena Gebala, Stephanie L Johnson ... Dan Herschlag
    First experimental studies on the ion atmosphere around a nucleosome provide a quantitative analysis of the molecule's electrostatic properties.