6,504 results found
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    A new topology of the HK97-like fold revealed in Bordetella bacteriophage by cryoEM at 3.5 Å resolution

    Xing Zhang, Huatao Guo ... Z Hong Zhou
    Cryo electron microscopy and structure-based mutagenesis reveal that the bacteriophage BPP-1 contains two of the three major recognized viral folds, one of which exhibits a new topology.
    1. Evolutionary Biology
    2. Neuroscience

    Proposing a neural framework for the evolution of elaborate courtship displays

    Ryan W Schwark, Matthew J Fuxjager, Marc F Schmidt
    The midbrain periaqueductal grey is a conserved mediator of elaborate courtship behavior in a range of vertebrate taxa, likely shaping how this behavior diversifies across the tree of life.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Genetic basis and dual adaptive role of floral pigmentation in sunflowers

    Marco Todesco, Natalia Bercovich ... Loren H Rieseberg
    Variation in patterns of floral UV pigmentation is controlled by a single transcription factor in sunflower and affects both pollinator attraction and responses to environmental stresses.
    1. Evolutionary Biology
    2. Neuroscience

    Divergent sensory investment mirrors potential speciation via niche partitioning across Drosophila

    Ian W Keesey, Veit Grabe ... Bill S Hansson
    Phototaxis and courtship behavioral preferences reflect strong correlation with differences in olfactory and visual nervous system investment across five monophyletic Drosophila species, and could help explain their speciation events.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolutionary dynamics of circular RNAs in primates

    Gabriela Santos-Rodriguez, Irina Voineagu, Robert J Weatheritt
    An analysis of the genomic features that distinguish conserved from species-specific circular RNAs reveals that the expansion of the downstream intron by insertion of retrotransposons stabilizes circular RNAs' production across 30+ millions years of evolution.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Synthetic single domain antibodies for the conformational trapping of membrane proteins

    Iwan Zimmermann, Pascal Egloff ... Markus A Seeger
    Synthetic single domain antibody libraries and a binder selection cascade encompassing ribosome and phage display enable the selection of conformation-specific binders against previously intractable membrane proteins within three weeks.
    1. Computational and Systems Biology
    2. Ecology

    A rapid phylogeny-based method for accurate community profiling of large-scale metabarcoding datasets

    Lenore Pipes, Rasmus Nielsen
    Tronko provides a scalable solution for accurate taxonomic assignment for large-scale metabarcoding datasets by overcoming the speed and memory limitations of previous phylogenetic placement methods.
    1. Evolutionary Biology

    Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies

    Angela M Phillips, Katherine R Lawrence ... Michael M Desai
    CR9114, one of the most broadly neutralizing anti-influenza antibodies characterized to date, acquires affinity to divergent HA subtypes sequentially, due to higher order interactions between the nested sets of mutations required for binding each distinct subtype.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Patterns of within-host genetic diversity in SARS-CoV-2

    Gerry Tonkin-Hill, Inigo Martincorena ... Wellcome Sanger Institute COVID-19 Surveillance Team
    Characterisation of within-host diversity of SARS-CoV-2 provides insights into the mutational and selective mechanisms driving its evolution and has important implications for using within-host variation to inform transmission inference efforts.
    1. Ecology
    2. Evolutionary Biology

    Parasite defensive limb movements enhance acoustic signal attraction in male little torrent frogs

    Longhui Zhao, Jichao Wang ... Jianguo Cui
    Multimodal signals may evolve from unimodal one via co-option of primary signal components and associated cues that serve as by-products.

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