2,796 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    The distribution of fitness effects among synonymous mutations in a gene under directional selection

    Eleonore Lebeuf-Taylor et al.
    Synonymous mutations can have highly variable fitness effects stemming from changes in transcription, some of which contribute to adaptation.
    1. Genetics and Genomics

    Regulatory network structure determines patterns of intermolecular epistasis

    Mato Lagator et al.
    Greater phenotypic variation is exposed by mutations in a gene regulatory system compared to mutations in its constitutive components, namely the transcription factor and the promoter, alone.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios

    Marc J Williams et al.
    Measurement of the distribution of fitness effects of new mutations arising in human oesophagus and skin, via new mathematical theory linking dn/ds values and fitness coefficients.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Point of View: Is cell size a spandrel?

    Ariel Amir
    Analysis of experiments on bacteria suggests that the dependence of cell size on growth rate is not an adaptation but a causal consequence of a regulatory mechanism that controls DNA replication.
    1. Developmental Biology

    The Natural History of Model Organisms: An organismal perspective on C. intestinalis development, origins and diversification

    Matthew J Kourakis, William C Smith
    The life cycle and morphology of the sea squirt Ciona intestinalis shed light on vertebrate evolution.
    1. Genetics and Genomics
    2. Human Biology and Medicine

    Point of View: Bioengineering horizon scan 2020

    Luke Kemp et al.
    20 emerging issues in bioengineering that will have profound impacts on society have been identified.
    1. Evolutionary Biology

    Population Genetics: Global clues to the nature of genomic mutations in humans

    Aylwyn Scally
    An analysis of worldwide human genetic variation reveals the footprints of ancient changes in genomic mutation processes.
    Insight
    Available as:
    • HTML
    • PDF
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Gene Variation: The double-edged sword of evolution

    Etty Kruzel-Davila, Karl Skorecki
    Two gene variants provide different levels of protection against sleeping sickness, but this comes with an increased risk of developing chronic kidney disease.
    Insight
    Available as:
    • HTML
    • PDF
    1. Microbiology and Infectious Disease

    Research: A comprehensive and quantitative exploration of thousands of viral genomes

    Gita Mahmoudabadi, Rob Phillips
    A compendium of critical genomic numbers for viruses through the lenses of different viral classification systems.

Refine your results by:

Type
Research categories