1,115 results found
    1. Cell Biology
    2. Evolutionary Biology

    Phylogenetic divergence of cell biological features

    Michael Lynch
    Cell biological features are subject to stochastic forces of mutation and random genetic drift, which together cause lineages exposed to identical selection pressures to diverge, and mean phenotypes to deviate from expectations under optimizing selection.
    1. Evolutionary Biology
    2. Plant Biology

    Natural selection and repeated patterns of molecular evolution following allopatric divergence

    Yibo Dong et al.
    The genomic architecture of allopatric species is a mosaic of many conserved genes and a few adaptive ones, reflecting balance between conservation of ancestral functions and evolution of new features.
    1. Developmental Biology
    2. Neuroscience

    Conserved and divergent development of brainstem vestibular and auditory nuclei

    Marcela Lipovsek, Richard JT Wingate
    The development of brainstem auditory nuclei echoes the divergent evolutionary history of amniote auditory systems.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Predominance of cis-regulatory changes in parallel expression divergence of sticklebacks

    Jukka-Pekka Verta, Felicity C Jones
    Cis-regulation such as enhancers and promoters plays a major role in parallel gene expression divergence and has features that make it a well-poised substrate for adaptive evolution.
    1. Structural Biology and Molecular Biophysics

    The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry

    Joseph Atherton et al.
    MKLP2 is a divergent molecular motor that has structurally evolved to bind its microtubule track and use the energy of ATP in distinct ways, tuned according to its function in cell division.
    1. Evolutionary Biology
    2. Neuroscience

    Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons

    Jing Qiu et al.
    The transcriptional response of human neurons to calcium ion signals shows evolutionary divergence from those responses elicited in mouse neurons, providing evidence in favour of using human systems to study neuronal responses to external stimuli.
    1. Biochemistry and Chemical Biology

    Immunoproteasome functions explained by divergence in cleavage specificity and regulation

    Michael B Winter et al.
    Divergence in immunoproteasome substrate specificity and regulation from the constitutive proteasome impacts peptide cleavage quantity and the cellular capacity of the ubiquitin-proteasome system.
    1. Developmental Biology
    2. Neuroscience

    Functional divergence of Plexin B structural motifs in distinct steps of Drosophila olfactory circuit assembly

    Ricardo Guajardo et al.
    Systematic in vivo analysis reveals the divergent engagement of Plexin B structural motifs in distinct neurodevelopmental processes and a regulatory role of convertase cleavage in Plexin B signaling.
    1. Evolutionary Biology
    2. Plant Biology

    Speciation: How predictable is genome evolution?

    Matthew J Coathup et al.
    Similar patterns of genomic divergence have been observed in the evolution of plant species separated by oceans.
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    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity

    Pierre Khoueiry et al.
    Interspecies comparison of transcription factor occupancy during embryogenesis reveals potential co-operative relationships between factors and uncovers the inherent plasticity of developmental enhancers to overcome divergence in transcription factor occupancy.

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