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    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    A recurrent regulatory change underlying altered expression and Wnt response of the stickleback armor plates gene EDA

    Natasha M O'Brown, Brian R Summers ... David M Kingsley
    An identical DNA base pair change has occurred in divergent sticklebacks to alter the expression of a major developmental gene controlling armor plates, thus providing a molecular link between particular enhancer changes, cell signaling, and repeated skeletal evolution in natural populations.
    1. Ecology
    2. Microbiology and Infectious Disease

    Mapping microbial ecosystems and spoilage-gene flow in breweries highlights patterns of contamination and resistance

    Nicholas A Bokulich, Jordyn Bergsveinson ... David A Mills
    Mapping microbial landscapes in indoor environments can predict how contaminants and spoilage resistance genes propagate within food-production environments, yielding novel insight for controlling spoilage.
    1. Genetics and Genomics
    2. Plant Biology

    Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite

    Mark McMullan, Anastasia Gardiner ... Jonathan DG Jones
    Hybridization and introgression blur species boundaries and broaden genetic diversity available for adaptation; and widespread introgression underpins the evolution of races of the generalist pathogen Albugo candida that specialise on different host plant species.
    1. Cell Biology

    COMP-1 promotes competitive advantage of nematode sperm

    Jody M Hansen, Daniela R Chavez, Gillian M Stanfield
    Nematode sperm respond to competitive environments by modulating cellular pathways involved in migration and storage to ensure their access to oocytes.
    1. Developmental Biology
    2. Genetics and Genomics

    Constraint and divergence of global gene expression in the mammalian embryo

    Noah Spies, Cheryl L Smith ... Arend Sidow
    Embryonic gene expression is strongly influenced by maternal genetic variation and by embryonic variation that acts in cis but not in trans.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling

    Nicolas Aznar, Krishna K Midde ... Pradipta Ghosh
    Daple is a guanine nucleotide-exchange factor (GEF) for trimeric G proteins that enables Wnt/Frizzled receptors to transactivate G proteins during non-canonical Wnt signaling.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Mitotic fidelity requires transgenerational action of a testis-restricted HP1

    Mia T Levine, Helen M Vander Wende, Harmit S Malik
    Analysis of a spermiogenesis protein reveals a new chromatin requirement for synchrony between maternal DNA packaged in the egg and sperm-packaged paternal DNA in the first embryonic mitosis in Drosophila melanogaster.
    1. Developmental Biology
    2. Neuroscience

    Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons

    Timothy A Evans, Celine Santiago ... Greg J Bashaw
    The Roundabout2 receptor acts non-autonomously to promote commissural axons to cross the midline by antagonizing Slit-dependent axon repulsion.
    1. Cell Biology
    2. Genetics and Genomics

    Selections that isolate recombinant mitochondrial genomes in animals

    Hansong Ma, Patrick H O'Farrell
    Recombinant mitochondrial genomes can be selected, traits can be genetically mapped and new genetic combinations can be made.
    1. Stem Cells and Regenerative Medicine

    ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas

    Hanseul Yang, Daniel Schramek ... Elaine Fuchs
    Transcription factors of the ETS family govern a cohort of key cancer-associated regulators of malignancy in squamous cell carcinomas.