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    1. Evolutionary Biology
    2. Genetics and Genomics

    Predominance of cis-regulatory changes in parallel expression divergence of sticklebacks

    Jukka-Pekka Verta, Felicity C Jones
    Cis-regulation such as enhancers and promoters plays a major role in parallel gene expression divergence and has features that make it a well-poised substrate for adaptive evolution.
    1. Cancer Biology

    Shifting the focus of zebrafish toward a model of the tumor microenvironment

    Joshua M Weiss, Dianne Lumaquin-Yin ... Richard M White
    Zebrafish provide unique resources for the study of the tumor microenvironment.
    1. Ecology
    2. Evolutionary Biology

    Experimental evidence that group size generates divergent benefits of cooperative breeding for male and female ostriches

    Julian Melgar, Mads F Schou ... Charlie K Cornwallis
    Experimental manipulations of social groups of ostriches show that the benefits of cooperative parental care for females, and the costs of sexual competition for males, lead to sex differences in optimal group sizes.
    1. Genetics and Genomics

    Simultaneous quantification of mRNA and protein in single cells reveals post-transcriptional effects of genetic variation

    Christian Brion, Sheila M Lutz, Frank Wolfgang Albert
    A CRISPR-based dual reporter assay enables genetic mapping of DNA variants that specifically affect mRNA or protein levels in trans.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A large genomic insertion containing a duplicated follistatin gene is linked to the pea aphid male wing dimorphism

    Binshuang Li, Ryan D Bickel ... Jennifer A Brisson
    The application of long-read sequencing to the pea aphid wing dimorphism system reveals genomic structural divergence as a genetic mechanism of adaptation.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens

    Katherine Amberg-Johnson, Sanjay B Hari ... Ellen Yeh
    An unbiased chemical screen identifies the AAA+ membrane metalloprotease FtsH1 as a novel apicoplast biogenesis factor and druggable antimalarial target.
    1. Evolutionary Biology

    Adaptive substitutions underlying cardiac glycoside insensitivity in insects exhibit epistasis in vivo

    Andrew M Taverner, Lu Yang ... Peter Andolfatto
    Genome engineering and phenotyping in vivo reveal surprising new features of adaptive amino acid substitutions that were previously inaccessible.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Targeted surveillance strategies for efficient detection of novel antibiotic resistance variants

    Allison L Hicks, Stephen M Kissler ... Yonatan H Grad
    Sampling informed by pathogen genomic data may facilitate more efficient detection of novel antibiotic resistance than random sampling.
    1. Microbiology and Infectious Disease

    A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity

    Alyson Ashe, Tony Bélicard ... Eric A Miska
    Evidence that C. elegans and mammals use homologous versions of the same protein (RIG-1) to activate antiviral defense mechanisms suggests that RIG-1 may have a conserved role in coupling virus recognition to virus destruction.
    1. Evolutionary Biology

    Estimating dispersal rates and locating genetic ancestors with genome-wide genealogies

    Matthew Osmond, Graham Coop
    A new method to infer the spatial history of genetic ancestors from a sequence of trees along a recombining genome.