9,279 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms

    Alessandro Scacchetti et al.
    Alternative splicing of a single gene generates functional diversity amongst chromatin regulators.
    1. Cell Biology
    2. Developmental Biology

    Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules

    Patricia Giselle Cipriani et al.
    Two novel LOTUS-domain proteins are core germ granule components that directly recruit Caenorhabditis elegans Vasa, regulate germ granule size and localization, and provide an organizational framework for ribonucleoprotein complexes.
    1. Structural Biology and Molecular Biophysics

    High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generation

    Zhiguo Shang et al.
    Microtubule attachment fundamentally modifies kinesin's behavior by triggering a ‘clamshell’ opening of the nucleotide cleft, subsequently reversed by ATP binding, that couples to cargo translocation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Homology sensing via non-linear amplification of sequence-dependent pausing by RecQ helicase

    Yeonee Seol et al.
    The rate of DNA unwinding by RecQ helicases is dramatically modulated by the DNA duplex stability in a geometry-dependent manner, providing an intrinsic mechanism for suppressing illegitimate recombination.
    1. Evolutionary Biology
    2. Neuroscience

    A cerebellar substrate for cognition evolved multiple times independently in mammals

    Jeroen B Smaers et al.
    Multiple independent directional selection events on a neural substrate that underpins domain-general associative abilities partly explains independent occurrences of complex behavior in different lineages of mammals.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Learning protein constitutive motifs from sequence data

    Jérôme Tubiana et al.
    A new machine-learning toolbox unveils coevolutionary protein motifs related to structure, function, and phylogeny from sequence information only.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Combinations of Spok genes create multiple meiotic drivers in Podospora

    Aaron A Vogan et al.
    Members of a single gene family determine the genomic basis of multiple coexisting meiotic drive elements in natural populations of Podospora.
    1. Stem Cells and Regenerative Medicine

    Long-term live imaging of the Drosophila adult midgut reveals real-time dynamics of division, differentiation and loss

    Judy Lisette Martin et al.
    A new platform for imaging live Drosophila adults yields vivid movies of the midgut over prolonged time scales, opening the door to the real-time study of organ renewal dynamics in a near-native context.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Universal and taxon-specific trends in protein sequences as a function of age

    Jennifer E James et al.
    Ancient protein domains remain shaped by amino acid availability during early life, while young animal proteins are shaped by a need for high intrinsic structural disorder.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation

    Kacper B Rogala et al.
    SAS-5 forms oligomers, through a trimeric coiled coil and novel dimeric domain, that are necessary for centriolar localisation of SAS-5 and for centriole duplication.

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