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    1. Neuroscience

    Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances the learning of cue-reward contingency

    Richard B Crouse et al.
    The release of acetylcholine in the basolateral amygdala is precisely timed to salient events during reward learning but has long-lasting effects that potentiate learning of cue-reward contingencies.
    1. Neuroscience

    Ultra-high-field imaging reveals increased whole brain connectivity underpins cognitive strategies that attenuate pain

    Enrico Schulz et al.
    A single-trial whole-brain analysis of three cognitive strategies to attenuate pain shows that a more effective pain attenuation is associated with increased functional connectivity across the entire brain.
    1. Neuroscience

    Performance in even a simple perceptual task depends on mouse secondary visual areas

    Hannah C Goldbach et al.
    In a simple visual task, that in principle could be performed using information in V1 alone, perturbations of secondary visual areas impair perception.
    1. Genetics and Genomics

    Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging

    Sebastian I Arriola Apelo et al.
    Metabolic health and longevity can be separated by ovariectomy, which also protects female mice lacking hepatic mTORC2 from midlife mortality.
    1. Immunology and Inflammation

    A novel role for lipoxin A4 in driving a lymph node–eye axis that controls autoimmunity to the neuroretina

    Jessica Wei et al.
    LXA4 in lymph nodes is an important resident homeostatic regulator that controls effector T cell functions and egress in the development of adaptive immune responses.
    1. Neuroscience

    Orbitofrontal neurons signal sensory associations underlying model-based inference in a sensory preconditioning task

    Brian F Sadacca et al.
    Neural activity in the orbitofrontal cortex (OFC) represents incidental stimulus-stimulus associations, providing additional evidence for OFC having a role in cognition beyond functions centered on processing value or biological significance.
    1. Neuroscience

    Frontal cortex selects representations of the talker’s mouth to aid in speech perception

    Muge Ozker et al.
    During speech perception, if auditory speech is not informative the frontal cortex will enhance responses in visual regions that represent the mouth of the talker to improve perception.
    1. Cancer Biology

    Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice

    Shun Kishimoto et al.
    Using noise suppression, real-time imaging of glucose metabolism is possible by 13C MRI and reveals previously undetected metabolic differences within tumors.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Mapping cell type-specific transcriptional enhancers using high affinity, lineage-specific Ep300 bioChIP-seq

    Pingzhu Zhou et al.
    A method for measuring p300 chromatin occupancy in specific lineages of mouse tissues was used to map endothelial enhancers and to identify previously unrecognized angiogenesis-related sequence motifs.
    1. Computational and Systems Biology
    2. Cancer Biology

    Expression signature based on TP53 target genes doesn't predict response to TP53-MDM2 inhibitor in wild type TP53 tumors

    Dmitriy Sonkin
    A previously suggested expression signature based on thirteen TP53 transcriptional target genes does not predict the response of wild type TP53 tumors to TP53-MDM2 inhibitors.