258 results found
    1. Neuroscience

    Attenuation of dopamine-modulated prefrontal value signals underlies probabilistic reward learning deficits in old age

    Lieke de Boer et al.
    Attenuated anticipatory activity in ventromedial prefrontal cortex is modulated by dopamine D1 receptor density in nucleus accumbens, and accounts for impaired probabilistic reward learning in older adults.
    1. Cell Biology
    2. Neuroscience

    Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter

    Tatiana Sorkina et al.
    Dopamine transporter (DAT) interaction with furopyrimidine called AIM-100 in intact cells leads to dramatic oligomerization, nanoclustering and endocytosis of DAT by a novel mechanism coupled to the transporter molecule conformation.
    1. Neuroscience

    Retroactive modulation of spike timing-dependent plasticity by dopamine

    Zuzanna Brzosko et al.
    Dopamine, a reward signal in the brain, can retroactively convert hippocampal synaptic depression into potentiation, suggesting an elegant biological solution to the distal reward problem.
    1. Neuroscience

    A genetic link between discriminative fear coding by the lateral amygdala, dopamine, and fear generalization

    Graham L Jones et al.
    Discrimination of predictive and non-predictive fear stimuli requires plasticity in the lateral amygdala that is regulated by midbrain dopamine neurons.
    1. Neuroscience

    Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis

    Nicolas X Tritsch et al.
    The molecular mechanisms by which midbrain dopamine neurons acquire the inhibitory neurotransmitter GABA for synaptic release are revealed.
    1. Neuroscience

    Opposite initialization to novel cues in dopamine signaling in ventral and posterior striatum in mice

    William Menegas et al.
    Dopamine novelty signals are localized in the posterior tail of the striatum along with general salience signals, while dopamine in the ventral striatum reliably encodes reward prediction error.
    1. Neuroscience

    Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass

    William Menegas et al.
    Dopamine neurons projecting to different targets receive a similar set of inputs, rather than forming reciprocal connections, whereas those projecting to the posterior striatum receive a distinct set of inputs.
    1. Neuroscience

    Midbrain dopamine neurons compute inferred and cached value prediction errors in a common framework

    Brian F Sadacca et al.
    Midbrain dopamine neurons in rats signal discrepancies between predicted and actual rewards, regardless of whether the rewards are predicted on the basis of experience or inference.
    1. Neuroscience

    Effects of dopamine on reinforcement learning and consolidation in Parkinson’s disease

    John P Grogan et al.
    Memory over 24 hours was impaired in Parkinson's patients off, rather than on, dopaminergic medication during reinforcement learning, whereas dopamine did not affect positive and negative reinforcement, in contrast to previous studies.
    1. Neuroscience

    Emergence of visually-evoked reward expectation signals in dopamine neurons via the superior colliculus in V1 lesioned monkeys

    Norihiro Takakuwa et al.
    The subcortical visual pathway through the midbrain superior colliculus is responsible for visually evoked Pavlovian conditioning and dopamine neuron responses with predicted value in monkeys, which remained after lesioning V1.

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