Ariane C Boehm, Anja B Friedrich ... Ilona C Grunwald Kadow
Behavioral and in vivo imaging analysis in the fly suggests that mating-related sensory experience regulates female odor perception and expression of choice behavior through a dopamine-gated learning circuit.
Frontal cortical circuit alterations and cognitive deficits identified in mouse genetic models are reversed by chemogenetic or optogenetic stimulation of the mesocortical dopamine circuit in an adolescent period.
Prefrontal dopamine regulates inhibition of fear extinction circuits in the infralimbic cortex and disinhibition of fear expression circuits in the amygdala, leading to fear reinstatement.
A recurrent reward circuit in Drosophila, comprised of specific dopamine neurons and a single class of mushroom body output neurons, transforms a nascent memory trace into a stable long-term memory.
In nematode worms, the length of the male refractory period–the time between matings–is regulated by multiple transmitters including dopamine, which both promotes ejaculation and reduces the activity of males post-copulation.
Nathan Cermak, Stephanie K Yu ... Steven W Flavell
Simultaneous quantification of each of the main motor programs in the roundworm C. elegans yields new insights into the neural mechanisms that coordinate animal behavior.
Mingzheng Wu, Samuel Minkowicz ... Yevgenia Kozorovitskiy
Interconnected ventral tegmental area and medial prefrontal cortex circuits causally link dopamine dynamics, aversive learning, and the effects of a promising rapidly acting antidepressant ketamine.
Alcohol modifies dopaminergic microcircuits required for acquisition and expression of sensory memories in Drosophila resulting in a shift in behavioral response from malleable to inflexible.
Jose Ernesto Canton-Josh, Joanna Qin ... Yevgenia Kozorovitskiy
For cerebellar unipolar brush cells that regulate information flow to the vestibulo-cerebellum, dopaminergic modulation by locus coeruleus axons presents a new example of monoaminergic co-release poised to regulate the activity of the cerebellar cortex.