674 results found
    1. Neuroscience

    A dopamine-gated learning circuit underpins reproductive state-dependent odor preference in Drosophila females

    Ariane C Boehm, Anja B Friedrich ... Ilona C Grunwald Kadow
    Behavioral and in vivo imaging analysis in the fly suggests that mating-related sensory experience regulates female odor perception and expression of choice behavior through a dopamine-gated learning circuit.
    1. Neuroscience

    Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function

    Surjeet Mastwal, Xinjian Li ... Kuan Hong Wang
    Frontal cortical circuit alterations and cognitive deficits identified in mouse genetic models are reversed by chemogenetic or optogenetic stimulation of the mesocortical dopamine circuit in an adolescent period.
    1. Neuroscience

    Prefrontal dopamine regulates fear reinstatement through the downregulation of extinction circuits

    Natsuko Hitora-Imamura, Yuki Miura ... Hiroshi Nomura
    Prefrontal dopamine regulates inhibition of fear extinction circuits in the infralimbic cortex and disinhibition of fear expression circuits in the amygdala, leading to fear reinstatement.
    1. Neuroscience

    Neuromodulation of excitatory synaptogenesis in striatal development

    Yevgenia Kozorovitskiy, Rui Peixoto ... Bernardo L Sabatini
    Protein kinase A regulates the rapid, activity-dependent genesis of excitatory synapses during striatal development.
    1. Neuroscience

    Reward signal in a recurrent circuit drives appetitive long-term memory formation

    Toshiharu Ichinose, Yoshinori Aso ... Hiromu Tanimoto
    A recurrent reward circuit in Drosophila, comprised of specific dopamine neurons and a single class of mushroom body output neurons, transforms a nascent memory trace into a stable long-term memory.
    1. Neuroscience

    Caenorhabditis elegans male sensory-motor neurons and dopaminergic support cells couple ejaculation and post-ejaculatory behaviors

    Brigitte LeBoeuf, Paola Correa ... L René García
    In nematode worms, the length of the male refractory period–the time between matings–is regulated by multiple transmitters including dopamine, which both promotes ejaculation and reduces the activity of males post-copulation.
    1. Neuroscience

    Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans

    Nathan Cermak, Stephanie K Yu ... Steven W Flavell
    Simultaneous quantification of each of the main motor programs in the roundworm C. elegans yields new insights into the neural mechanisms that coordinate animal behavior.
    1. Neuroscience

    Attenuated dopamine signaling after aversive learning is restored by ketamine to rescue escape actions

    Mingzheng Wu, Samuel Minkowicz ... Yevgenia Kozorovitskiy
    Interconnected ventral tegmental area and medial prefrontal cortex circuits causally link dopamine dynamics, aversive learning, and the effects of a promising rapidly acting antidepressant ketamine.
    1. Neuroscience

    Circuits that encode and guide alcohol-associated preference

    Kristin M Scaplen, Mustafa Talay ... Karla R Kaun
    Alcohol modifies dopaminergic microcircuits required for acquisition and expression of sensory memories in Drosophila resulting in a shift in behavioral response from malleable to inflexible.
    1. Neuroscience

    Dopaminergic regulation of vestibulo-cerebellar circuits through unipolar brush cells

    Jose Ernesto Canton-Josh, Joanna Qin ... Yevgenia Kozorovitskiy
    For cerebellar unipolar brush cells that regulate information flow to the vestibulo-cerebellum, dopaminergic modulation by locus coeruleus axons presents a new example of monoaminergic co-release poised to regulate the activity of the cerebellar cortex.

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