323 results found
    1. Neuroscience

    Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons

    Rachel S Lee et al.
    Despite the fundamental relationship between movement and value, they are represented in a separable manner in dopamine neurons.
    1. Neuroscience

    Coordination of rapid cholinergic and dopaminergic signaling in striatum during spontaneous movement

    Mark Howe et al.
    Optical recordings reveal previously unknown neuromodulator dynamics in the striatum during animal movements that suggest a new interpretation of the underpinnings of bradykinetic movements exhibited in Parkinson's Disease patients.
    1. Neuroscience

    Valence-encoding in the lateral habenula arises from the entopeduncular region

    Hao Li et al.
    Lateral habenula neurons participate in motivated behavior via their activation by negative affective stimuli, a major source of which arises from the rostral entopeduncular nucleus.
    1. Neuroscience

    Sensory prediction errors in the human midbrain signal identity violations independent of perceptual distance

    Javier A Suarez et al.
    Activity in the midbrain responds to unexpected changes in outcome identity (i.e. sensory prediction error) but does not scale with perceptual distance between expected and receipt reward.
    1. Developmental Biology
    2. Neuroscience

    Chronology-based architecture of descending circuits that underlie the development of locomotor repertoire after birth

    Avinash Pujala, Minoru Koyama
    Newly forming descending pathways are arranged to function in parallel to existing ones and contribute to increasingly sophisticated locomotor behaviors that emerge postnatally with suitable connectivity patterns and biophysical properties.
    1. Neuroscience

    Locomotion: Building behaviors, one layer at a time

    Claire Wyart, Vatsala Thirumalai
    New interneurons are added in the hindbrain to support more complex movements as young zebrafish get older.
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    1. Cell Biology

    Luciferase-LOV BRET enables versatile and specific transcriptional readout of cellular protein-protein interactions

    Christina K Kim et al.
    SPARK2 allows a transcriptional readout of inter- and intracellular protein-protein interactions, with near-zero background, by employing proximity-dependent luciferase-LOV regulation.
    1. Cell Biology
    2. Plant Biology

    Kinetochore protein depletion underlies cytokinesis failure and somatic polyploidization in the moss Physcomitrella patens

    Elena Kozgunova et al.
    Lagging chromosomes in anaphase inhibits cytokinesis in plant cells.
    1. Neuroscience

    Neuronal reactivation during post-learning sleep consolidates long-term memory in Drosophila

    Ugur Dag et al.
    Consolidation of long-term courtship memory in Drosophila is mediated by a novel class of sleep promoting neurons that reactivates dopaminergic neurons engaged earlier in memory acquisition during post-learning sleep.
    1. Neuroscience

    Neurocalcin regulates nighttime sleep and arousal in Drosophila

    Ko-Fan Chen et al.
    The neuronal calcium sensor Neurocalcin regulates sleep and arousal thresholds during the night in Drosophila.

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