359 results found
    1. Ecology
    2. Evolutionary Biology

    Seminal fluid compromises visual perception in honeybee queens reducing their survival during additional mating flights

    Joanito Liberti et al.
    After insemination, honeybee queens experience a rapid reduction in vision and flight performance, consistent with an ongoing sexual conflict over the number of mating flights that queens embark on.
    1. Neuroscience

    The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats

    Paolo Campus et al.
    A top-down circuit generating from the prelimbic cortex and projecting to the paraventricular nucleus of the thalamus mediates individual differences in cue-elicited responding by affecting subcortical dopamine-dependent incentive learning.
    1. Neuroscience

    HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons

    Niklas Byczkowicz et al.
    The cAMP-HCN pathway can control action potential conduction velocity providing neuromodulators with the ability to tune energy consumption and temporal delays across axons in the brain.
    1. Cell Biology

    Regulator of G protein signaling 12 enhances osteoclastogenesis by suppressing Nrf2-dependent antioxidant proteins to promote the generation of reactive oxygen species

    Andrew Ying Hui Ng et al.
    Rgs12 protein is a novel regulator of the Nrf2 protein by facilitating the proteasomal degradation of the transcription factor during osteoclast differentiation.
    1. Neuroscience

    An open cortico-basal ganglia loop allows limbic control over motor output via the nigrothalamic pathway

    Sho Aoki et al.
    A novel connection from ventral striatum to motor cortex enables emotion and motivation to influence action and motor control.
    1. Neuroscience

    Neuropeptide F regulates courtship in Drosophila through a male-specific neuronal circuit

    Weiwei Liu et al.
    Functional dissection of a cluster of male-specific neurons in Drosophila reveals a neuronal circuit regulating male courtship in accordance with the internal drive state.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

    Emil Dandanell Agerschou et al.
    The high affinity α-synuclein-monomer binder AS69 converts into a strong sub-stoichiometric inhibitor of nucleation processes upon formation of the AS69-α-synuclein complex, achieving reduced aggregation in vitro and in vivo.
    1. Neuroscience

    Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels

    Francesco Tomassoni-Ardori et al.
    RbFox1 upregulation modulates the expression of hundreds of genes but only dysregulation of the TrkB.T1 receptor isoform expression causes BDNF-dependent LTP impairments.
    1. Neuroscience

    Neuroanatomy of a hydrothermal vent shrimp provides insights into the evolution of crustacean integrative brain centers

    Julia Machon et al.
    A neuroanatomical analysis of Rimicaris exoculata provides insights into these animal’s brain architecture to illustrate possible adaptations to the hydrothermal vent habitat with its extreme physicochemical conditions.
    1. Genetics and Genomics
    2. Neuroscience

    Taar1 gene variants have a causal role in methamphetamine intake and response and interact with Oprm1

    Alexandra M Stafford et al.
    The trace amine-associated receptor 1 gene has a causal role in methamphetamine intake and thermal response, and interacts with the mu-opioid receptor gene in its methamphetamine addiction-related effects.

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