344 results found
    1. Neuroscience

    Neuronal integration in the adult mouse olfactory bulb is a non-selective addition process

    Jean-Claude Platel et al.
    Adult neurogenesis in the olfactory bulb is not a turnover system but represents a lifelong neuronal addition mechanism.
    1. Neuroscience

    Task-induced functional brain connectivity mediates the relationship between striatal D2/3 receptors and working memory

    Matthew M Nour et al.
    Striatal dopamine 2/3 receptor (D2/3R) availability is related to working memory-induced functional connectivity changes in the default mode network, and this mediates the relationship between D2/3Rs and task performance.
    1. Neuroscience

    Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age

    Simone Kühn et al.
    Trajectories of adolescent drinking behavior between age 14 and 19 years can be predicted from bilateral striatal and cerebellar grey matter at 14 years of age.
    1. Neuroscience

    Transitioning between preparatory and precisely sequenced neuronal activity in production of a skilled behavior

    Vamsi K Daliparthi et al.
    Precisely sequenced patterns of neuronal activity associated with the production of a skilled behavior begin and end as part of orchestrated activity across functionally diverse populations of cortical premotor neurons.
    1. Developmental Biology
    2. Neuroscience

    Robo2 regulates synaptic oxytocin content by affecting actin dynamics

    Savani Anbalagan et al.
    Real-time monitoring of oxytocin-loaded vesicles and synaptic actin dynamics in zebrafish reveal that Slit3-Robo2-Cdc42 signalling maintains steady-state levels of mature oxytocin neuropeptide readily primed to be secreted upon physiological demand.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor

    Vanessa A Gutzeit et al.
    Single molecule subunit counting, FRET and electrophysiology experiments reveal that metabotropic glutamate receptor subunits interact and rearrange at the level of the transmembrane domains in response to allosteric modulators.
    1. Biochemistry and Chemical Biology

    The dynamic conformational landscape of the protein methyltransferase SETD8

    Shi Chen et al.
    Integrated experimental-computational approaches were implemented to reveal the dynamic conformational landscape of a biologically relevant protein methyltransferase SETD8 for functional annotation.
    1. Neuroscience

    Local online learning in recurrent networks with random feedback

    James M Murray
    A biologically plausible learning rule enables recurrent neural networks to model the way in which neural circuits use supervised learning to perform time-dependent computations.
    1. Cell Biology

    PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity

    Insook Jang et al.
    The major protein disulfide isomerase family member, PDIA1, is essential in beta cells of mice fed a high-fat diet to maintain glucose homeostasis, proinsulin maturation and organelle integrity.
    1. Neuroscience

    Mesolimbic dopamine projections mediate cue-motivated reward seeking but not reward retrieval in rats

    Briac Halbout et al.
    Inhibiting ventral tegmental dopamine neurons, or their inputs to nucleus accumbens, disrupts cue-motivated reward seeking in a manner that depends on the microstructure of behavior.

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