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    1. Neuroscience

    Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation

    Ali Mohebi, Val L Collins, Joshua D Berke
    In awake behaving rats, cholinergic interneurons in the nucleus accumbens drive dopamine release via nicotinic receptors, boosting motivation to work.
    1. Neuroscience

    A selective effect of dopamine on information-seeking

    Valentina Vellani, Lianne P de Vries ... Tali Sharot
    L-DOPA administration increases information-seeking about potential losses without impacting information-seeking about potential gains, and as a result, it reduces the effect of valence on information-seeking.
    1. Neuroscience

    Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement

    Julie Corre, Ruud van Zessen ... Christian Lüscher
    Disinhibition of dopamine neurons in the midbrain drives heroin reinforcement, the initial step towards opioid addiction.
    1. Neuroscience

    Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis

    Nicolas X Tritsch, Won-Jong Oh ... Bernardo L Sabatini
    The molecular mechanisms by which midbrain dopamine neurons acquire the inhibitory neurotransmitter GABA for synaptic release are revealed.
    1. Neuroscience

    Cortical beta oscillations map to shared brain networks modulated by dopamine

    Meera Chikermane, Liz Weerdmeester ... Wolf Julian Neumann
    Invasively recorded cortical beta oscillations form whole-brain structural and functional networks that are modulated by dopamine.
    1. Neuroscience

    Midbrain dopamine neurons compute inferred and cached value prediction errors in a common framework

    Brian F Sadacca, Joshua L Jones, Geoffrey Schoenbaum
    Midbrain dopamine neurons in rats signal discrepancies between predicted and actual rewards, regardless of whether the rewards are predicted on the basis of experience or inference.
    1. Neuroscience

    Effects of dopamine D2/3 and opioid receptor antagonism on the trade-off between model-based and model-free behaviour in healthy volunteers

    Nace Mikus, Sebastian Korb ... Christoph Mathys
    Blocking D2 dopamine receptors increases goal-directed (“model-based”) control when alternative habitual ("model-free") actions are available, whereas blocking opioid receptors does not seem to have an effect on the arbitration between the two modes of acting.
    1. Neuroscience

    A dopamine-gated learning circuit underpins reproductive state-dependent odor preference in Drosophila females

    Ariane C Boehm, Anja B Friedrich ... Ilona C Grunwald Kadow
    Behavioral and in vivo imaging analysis in the fly suggests that mating-related sensory experience regulates female odor perception and expression of choice behavior through a dopamine-gated learning circuit.
    1. Neuroscience

    Auditory mismatch responses are differentially sensitive to changes in muscarinic acetylcholine versus dopamine receptor function

    Lilian Aline Weber, Sara Tomiello ... Klaas Enno Stephan
    Biperiden, but not amisulpride, delays auditory mismatch responses during environmental stability, suggesting a differential sensitivity of auditory statistical learning to muscarinic versus dopaminergic receptor status which could prove useful for developing tests that predict an individual's response to antipsychotic treatment.
    1. Neuroscience

    β2-subunit alternative splicing stabilizes Cav2.3 Ca2+ channel activity during continuous midbrain dopamine neuron-like activity

    Anita Siller, Nadja T Hofer ... Jörg Striessnig
    Regulation of Cav2.3 Ca2+ channels by membrane-bound β2 subunit splice variants permits long-lasting channel activity even during prolonged and continuous activity in dopamine neurons, with implications for Parkinson's disease pathophysiology.