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    1. Developmental Biology
    2. Neuroscience

    A cellular and regulatory map of the GABAergic nervous system of C. elegans

    Marie Gendrel, Emily G Atlas, Oliver Hobert
    GABAergic neurons in the nervous system of C. elegans have been comprehensively mapped allowing analysis of regulatory factors that program GABAergic neuron identity.
    1. Neuroscience

    Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1

    J Elliott Robinson, Gerard M Coughlin ... Viviana Gradinaru
    Heterozygous Nf1 knockout mice exhibit distinct dopaminergic phenotypes in vivo, as revealed by the genetically encoded dopamine sensor dLight1, patch clamp electrophysiology, optogenetics, and novel viral tools for morphological analysis.
    1. Neuroscience

    Sound exposure dynamically induces dopamine synthesis in cholinergic LOC efferents for feedback to auditory nerve fibers

    Jingjing Sherry Wu, Eunyoung Yi ... Elisabeth Glowatzki
    Based on the animal’s recent history of sound exposure, cholinergic auditory brainstem neurons dynamically regulate dopamine synthesis for inhibitory feedback to the inner ear.
    1. Neuroscience

    ExSTED microscopy reveals contrasting functions of dopamine and somatostatin CSF-c neurons along the lamprey central canal

    Elham Jalalvand, Jonatan Alvelid ... Ilaria Testa
    Expansion microscopy combined with light-sheet and STED microscopy elucidated the spatial organization and subcellular composition of two distinct GABAergic CSF-c neuronal subtypes in the lamprey spinal cord.
    1. Computational and Systems Biology

    Neural arbitration between social and individual learning systems

    Andreea Oliviana Diaconescu, Madeline Stecy ... Philippe N Tobler
    Arbitration is formalised as the relative precision of predictions afforded by reward and social learning systems and is represented in modality-specific dopaminergic and dopaminoceptive regions, including the midbrain and amygdala.
    1. Neuroscience

    Opioid antagonism modulates wanting-related frontostriatal connectivity

    Alexander Soutschek, Susanna C Weber ... Philippe N Tobler
    Reducing activation of opioidergic receptors strengthens the communication between control and reward circuits in the brain during hedonic judgements.
    1. Neuroscience

    Dopamine signaling tunes spatial pattern selectivity in C. elegans

    Bicheng Han, Yongming Dong ... Jihong Bai
    Natural variations in touch-dependent dopamine signaling tune the perception of spatial patterns in C. elegans.
    1. Neuroscience

    Live calcium and mitochondrial imaging in the enteric nervous system of Parkinson patients and controls

    An-Sofie Desmet, Carla Cirillo ... Pieter Vanden Berghe
    In contrast to previous post-mortem or fixed tissue histochemical reports, live calcium and mitochondrial imaging data suggest that the enteric nervous system is not generally affected in Parkinson's disease patients.
    1. Genetics and Genomics
    2. Neuroscience

    Orai-mediated calcium entry determines activity of central dopaminergic neurons by regulation of gene expression

    Rishav Mitra, Shlesha Richhariya, Gaiti Hasan
    Expression of the appropriate repertoire of membrane channels, essential for activity of flight-promoting central dopaminergic neurons of Drosophila, requires store-operated Ca2+ entry during late pupal development and early adults.
    1. Neuroscience

    Dopaminergic challenge dissociates learning from primary versus secondary sources of information

    Alicia J Rybicki, Sophie L Sowden ... Jennifer L Cook
    Haloperidol comparably affects learning from social and non-social sources when they are the primary source of information but does not affect learning from (social or non-social) secondary sources, providing evidence in support of domain-general neurochemical mechanisms underpinning social learning.