124 results found
    1. Neuroscience

    Neuronal sequences during theta rely on behavior-dependent spatial maps

    Eloy Parra-Barrero, Kamran Diba, Sen Cheng
    A computational framework and analysis of rodent CA1 data reveals that theta oscillations sequentially sweep through the past, present, and future at a spatial scale that varies with the characteristic speed of the animal.
    1. Neuroscience

    A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity

    Lea Ankri, Zoé Husson ... Marylka Yoe Uusisaari
    The glycinergic neurons of the cerebellar nuclei project extensively to the cerebellar cortex and inhibit GABAergic Golgi cells.
    1. Neuroscience

    Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues

    Adam Glaser, Jayaram Chandrashekar ... Karel Svoboda
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Regulation of multiple signaling pathways promotes the consistent expansion of human pancreatic progenitors in defined conditions

    Luka Jarc, Manuj Bandral ... Anthony Gavalas
    The signaling requirements to decouple proliferation of pancreatic progenitors from differentiation were elucidated and employed for the reproducible expansion, under GMP-compliant conditions, of pancreatic progenitors derived from different human pluripotent stem cell lines.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Stem cell niche exit in C. elegans via orientation and segregation of daughter cells by a cryptic cell outside the niche

    Kacy L Gordon, Jay W Zussman ... David R Sherwood
    A previously undetected dynamic cell structure orients the mitotic spindle of germ stem cells and grows over one daughter cell, thus helping to balance niche retention with niche exit.
    1. Developmental Biology
    2. Genetics and Genomics

    A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes

    Joo Lee, Caitlin A Taylor ... Kang Shen
    First comprehensive genetic analysis of a Myt1 family protein reveals that neurogenesis requires direct repression of non-neuronal identities by the Myt1 family protein through MuvB co-repressor complex.
    1. Neuroscience

    Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins

    Sharon Inberg, Yael Iosilevskii ... Benjamin Podbilewicz
    Mechanosensory isolation of C. elegans nematodes independently induces homeostatic structural changes in the dendritic tree and differential response to mechanical stimulation, both these structural and behavioral outcomes are mediated by degenerins and do not affect presynaptic calcium dynamics.
    1. Cell Biology
    2. Developmental Biology

    Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death

    Fabrice Bouilloux, Jérôme Thireau ... Frédéric Marmigère
    The transcription factor Meis1 is a dedicated maintenance factor for sympathetic neurons and controls the expression of key genes involved in endosome trafficking.
    1. Neuroscience

    Striatal cholinergic interneuron pause response requires Kv1 channels, is absent in dyskinetic mice, and is restored by dopamine D5 receptor inverse agonism

    Cecilia Tubert, Rodrigo M Paz ... Mario G Murer
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    The pelvic organs receive no parasympathetic innervation

    Margaux Sivori, Bowen Dempsey ... Jean-François Brunet
    Of the two divisions proposed long ago to describe the autonomic nervous system, thoraco-lumbar sympathetic and cranio-sacral parasympathetic, the latter finds no support from transcriptionally defined neuron types.
    Version of Record
    Short Report
    • Useful
    • Incomplete

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