4,285 results found
    1. Developmental Biology
    2. Evolutionary Biology

    Two consecutive microtubule-based epithelial seaming events mediate dorsal closure in the scuttle fly Megaselia abdita

    Juan Jose Fraire-Zamora et al.
    Evolutionary reduction in tissue number involves the simplification of the seaming process but not signaling during epithelial fusion.
    1. Cell Biology

    Crumbs is an essential regulator of cytoskeletal dynamics and cell-cell adhesion during dorsal closure in Drosophila

    David Flores-Benitez, Elisabeth Knust
    The evolutionarily conserved polarity protein Crumbs links the regulation of cytoskeleton dynamics and cell-cell adhesion with epithelial morphogenesis.
    1. Cell Biology
    2. Developmental Biology

    Cytoskeletal tension and Bazooka tune interface geometry to ensure fusion fidelity and sheet integrity during dorsal closure

    Piyal Taru Das Gupta, Maithreyi Narasimha
    Restoration of molecular and morphological symmetry and mechanical integrity following epithelial fusion relies on adaptive changes that are mediated by cytoskeletal tension and Bazooka dependent modulation of fusing interface geometry.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cell Signaling: Uncovering the secret life of Rho GTPases

    Jenna A Perry, Amy Shaub Maddox
    New methods to directly visualize Rho GTPases reveal how a protein called RhoGDI regulates the activity of these 'molecular switches' at the plasma membrane.
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    1. Computational and Systems Biology

    Point of View: Data science for the scientific life cycle

    Daphne Ezer, Kirstie Whitaker
    Each stage of the scientific life cycle stands to benefit from the introduction of data science techniques.
  1. Meta-Research: How significant are the public dimensions of faculty work in review, promotion and tenure documents?

    Juan P Alperin et al.
    An analysis of review, promotion and tenure documents from 129 US and Canadian universities suggests institutions could better fulfill their public missions by changing how they incentivize the public dimensions of faculty work.
    1. Genetics and Genomics

    Neurodevelopmental Disorders: Beyond protein-coding genes

    Anna Lozano-Ureña, Sacri R Ferrón
    A long non-coding RNA called lnc-NR2F1 regulates several neuronal genes, including some involved in autism and intellectual disabilities.
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    1. Computational and Systems Biology

    Meta-Research: Incidences of problematic cell lines are lower in papers that use RRIDs to identify cell lines

    Zeljana Babic et al.
    The use of Research Resource Identifiers (RRIDs) improves the proper use of cell lines in the biomedical literature.
    1. Cell Biology
    2. Neuroscience

    2018 Gairdner Awards: The past, present and future of light-gated ion channels and optogenetics

    Sheena A Josselyn
    Research into light-gated ion channels called channelrhodospins laid the foundations for the development of optogenetics, a technique that has gone on to revolutionize neuroscience.

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