3,218 results found
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Self-assembling manifolds in single-cell RNA sequencing data

    Alexander J Tarashansky, Yuan Xue ... Bo Wang
    An iterative self-assembling algorithm identifies the intrinsic structures in single-cell transcriptomic data and helps to discover new cell populations that are undetectable by existing methods.
    1. Neuroscience

    Beta band oscillations in motor cortex reflect neural population signals that delay movement onset

    Preeya Khanna, Jose M Carmena
    Using a sequential neurofeedback-arm reaching task, a new link is established among population neural activity patterns, generation of beta oscillations, and motor behavior changes.
    1. Neuroscience

    Attention-related modulation of caudate neurons depends on superior colliculus activity

    James P Herman, Fabrice Arcizet, Richard J Krauzlis
    The pattern of spatial attention preferences in caudate neurons is altered by superior colliculus inactivation, demonstrating that a superior colliculus to basal ganglia link is important for selective attention.
    1. Neuroscience

    A statistical framework to assess cross-frequency coupling while accounting for confounding analysis effects

    Jessica K Nadalin, Louis-Emmanuel Martinet ... Mark A Kramer
    A new measure for cross-frequency coupling assesses phase-amplitude coupling and amplitude-amplitude coupling, and accounts for confounding factors such as low-frequency amplitude fluctuations, using a flexible statistical modeling approach.
    1. Developmental Biology
    2. Neuroscience

    USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin

    Chien-Hsiang Wang, Yi-Chun Huang ... Cheng-Ting Chien
    Maintenance of ubiquitin homeostasis is essential for proper control of the size of postsynaptic density and the growth of specialized membrane structure.
    1. Neuroscience

    Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish

    Chanpreet Singh, Grigorios Oikonomou, David A Prober
    Experiments in genetically modified zebrafish that are unable to produce norepinephrine show that this neurotransmitter promotes wakefulness by mediating the effects of the neuropeptide hypocretin.
    1. Ecology

    Tritrophic metabolism of plant chemical defenses and its effects on herbivore and predator performance

    Ruo Sun, Xingcong Jiang ... Daniel Giddings Vassão
    Genetic manipulation demonstrates the costs and benefits of detoxifying glucosinolate plant defenses in a pest insect and its predator.
    1. Developmental Biology
    2. Neuroscience

    Cerebellar nuclei excitatory neurons regulate developmental scaling of presynaptic Purkinje cell number and organ growth

    Ryan T Willett, N Sumru Bayin ... Alexandra L Joyner
    The first born excitatory cerebellar nuclei neurons influence the survival of their Purkinje cell partners which stimulate the expansion of granule cells and interneurons to produce functional local circuits.
    1. Developmental Biology

    Extramacrochaetae regulates Notch signaling in the Drosophila eye through non-apoptotic caspase activity

    Sudershana Nair, Nicholas E Baker
    A member of the Inhibitor of DNA-binding (Id) gene family, best known as negative regulators of tissue-specific master regulatory bHLH transcription factors, also suppresses non-apoptotic caspase activities.
    1. Neuroscience

    Motion along the mental number line reveals shared representations for numerosity and space

    Caspar M Schwiedrzik, Benjamin Bernstein, Lucia Melloni
    Looking at visual motion affects perception of nonsymbolic numerosity in a direction-specific way, indicating that motion and number are computed by the same neurons.

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