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    1. Developmental Biology
    2. Plant Biology

    Quantitative analysis of auxin sensing in leaf primordia argues against proposed role in regulating leaf dorsoventrality

    Neha Bhatia, Henrik Åhl ... Marcus G Heisler
    Top-bottom patterning of leaves is not specified by an asymmetry in the distribution of the plant hormone auxin, in contrast to a previous proposal.
    1. Stem Cells and Regenerative Medicine

    In vivo generation of bone marrow from embryonic stem cells in interspecies chimeras

    Bingqiang Wen, Guolun Wang ... Vladimir V Kalinichenko
    Blastocyst complementation of rat embryos with donor mouse embryonic stem cells was used to simultaneously produce multiple, donor-derived hematopoietic and stromal cells in the interspecies bone marrow that exhibited normal gene expression signatures, cell surface markers, and functional characteristics.
    1. Neuroscience

    Calretinin positive neurons form an excitatory amplifier network in the spinal cord dorsal horn

    Kelly M Smith, Tyler J Browne ... Brett A Graham
    A signal amplifier network that transmits mechanical pain is delineated through characterising an excitatory interneuron population in the spinal cord dorsal horn and defining the postsynaptic populations they regulate.
    1. Neuroscience

    The subiculum is a patchwork of discrete subregions

    Mark S Cembrowski, Lihua Wang ... Nelson Spruston
    Pyramidal cells of the subiculum, a major output cell type of the hippocampus, can be deconstructed into distinct subtypes that exhibit a patchwork-like organization in space.
    1. Neuroscience

    Perceptual coupling and decoupling of the default mode network during mind-wandering and reading

    Meichao Zhang, Boris C Bernhardt ... Elizabeth Jefferies
    Functional neuroimaging in the human brain reveals the neurocognitive mechanisms that underpin the experience of mind-wandering during reading, explaining why comprehension is impaired.
    1. Computational and Systems Biology
    2. Developmental Biology

    A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning

    Qixuan Wang, Ji Won Oh ... Maksim V Plikus
    Regional differences in activator and inhibitor signals alter hair cycle pace across mouse skin and produce unique fur renewal 'landscapes', with fastest renewal on the ventrum and slowest renewal on the ear pinnae.
    1. Developmental Biology
    2. Neuroscience

    Embryonic origins of forebrain oligodendrocytes revisited by combinatorial genetic fate mapping

    Yuqi Cai, Zhirong Zhao ... Miao He
    Novel genetic fate-mapping strategies enabled re-analysis of cortical oligodendrocytes derived from dorsal pallium, LGE/CGE, and MGE/POA, challenging the canonical view of substantial LGE/CGE contributions and the elimination of MGE/POA-derived populations.
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    1. Developmental Biology
    2. Neuroscience

    Regulation of retinal axon growth by secreted Vax1 homeodomain protein

    Namsuk Kim, Kwang Wook Min ... Jin Woo Kim
    Secreted Vax1 homeodomain protein supports the development of optic chiasm by directly acting at the retinal ganglion cell axon.
    1. Computational and Systems Biology

    Quantitative perturbation-based analysis of gene expression predicts enhancer activity in early Drosophila embryo

    Rupinder Sayal, Jacqueline M Dresch ... David N Arnosti
    Mathematical modeling of mutagenesis data for a suite of enhancers uncovers new relationships between the binding sites of transcription factors that help in genome-wide prediction of enhancers.
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

    Benjamin W Okaty, Nikita Sturrock ... Susan M Dymecki
    Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.