3,857 results found
    1. Developmental Biology
    2. Plant Biology

    Temporal integration of auxin information for the regulation of patterning

    Carlos S Galvan-Ampudia, Guillaume Cerutti ... Teva Vernoux
    Rhythmic centrifugal waves of auxin traveling through the tissue provides high definition positional information to cells that is not only spatial but also temporal.
    1. Neuroscience

    Transforming descending input into behavior: The organization of premotor circuits in the Drosophila Male Adult Nerve Cord connectome

    Han SJ Cheong, Katharina Eichler ... Gwyneth M Card
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction

    Jacob M Winter, Heidi L Fresenius ... Jared Rutter
    A common genomic deletion in various human cancers disrupts mitochondrial protein homeostasis in a way that might be targeted by existing drugs.
    1. Cancer Biology
    2. Evolutionary Biology

    High-density sampling reveals volume growth in human tumours

    Arman Angaji, Michel Owusu ... Johannes Berg
    Spatial genomics reveals the mode of evolution of a tumour based on the positions of mutations in high-resolution samples.
    1. Neuroscience

    Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    François Kroll, Joshua Donnelly ... Jason Rihel
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Quantifying microbial fitness in high-throughput experiments

    Justus Wilhelm Fink, Michael Manhart
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology

    Efficient coding in biophysically realistic excitatory-inhibitory spiking networks

    Veronika Koren, Simone Blanco Malerba ... Stefano Panzeri
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Ecology
    2. Evolutionary Biology

    Spatiotemporal ecological chaos enables gradual evolutionary diversification without niches or tradeoffs

    Aditya Mahadevan, Michael T Pearce, Daniel S Fisher
    Evolution of multiple closely related strains with host-pathogen-like interactions but only one niche and no tradeoffs, can give rise to a spatiotemporally chaotic ecological state that continually diversifies even with generalist mutations that slow the evolution.
    1. Neuroscience

    A prefrontal network model operating near steady and oscillatory states links spike desynchronization and synaptic deficits in schizophrenia

    David A Crowe, Andrew Willow ... Bagrat Amirikian
    Cortical network model suggests a mechanism explaining the link between NMDAR synaptic and spike synchrony deficits observed in a pharmacological monkey model of prefrontal network failure in schizophrenia.
    1. Neuroscience

    Efficient sampling and noisy decisions

    Joseph A Heng, Michael Woodford, Rafael Polania
    An efficient coding theory for higher-level cognitive processes reveals that humans efficiently adapt to contextual distributions by economizing on environmental prior information.

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