371 results found
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology

    Quantitative imaging reveals real-time Pou5f3–Nanog complexes driving dorsoventral mesendoderm patterning in zebrafish

    Mireia Perez-Camps, Jing Tian ... Bruno Reversade
    Different combinations of the transcription factors Pou5f3, Nanog and Sox32 form complexes to drive dorsoventral mesendoderm patterning in zebrafish.
    1. Evolutionary Biology

    Striking parallels between dorsoventral patterning in Drosophila and Gryllus reveal a complex evolutionary history behind a model gene regulatory network

    Matthias Pechmann, Nathan James Kenny ... Siegfried Roth
    Crucial functions of Toll signalling during dorsoventral axis formation might have evolved convergently in flies and crickets.
    1. Developmental Biology

    A novel role for Ets4 in axis specification and cell migration in the spider Parasteatoda tepidariorum

    Matthias Pechmann, Matthew A Benton ... Siegfried Roth
    In the spider Parasteatoda tepidariorum the transcription factor Ets4 is needed for cumulus integrity, dorsoventral patterning and for the activation of hunchback and twist expression.
    1. Developmental Biology

    Dynamic BMP signaling polarized by Toll patterns the dorsoventral axis in a hemimetabolous insect

    Lena Sachs, Yen-Ta Chen ... Siegfried Roth
    During the evolution of insect lineages, a signaling pathway dedicated to pathogen defense was co-opted for a new role in embryonic patterning.
    1. Developmental Biology
    2. Neuroscience

    The differentiation and integration of the hippocampal dorsoventral axis are controlled by two nuclear receptor genes

    Xiong Yang, Rong Wan ... Ke Tang
    Two intrinsic factors converge to govern the differentiation and integration of distinct characteristics of the hippocampus in mice.
    1. Neuroscience

    Inter- and intra-animal variation in the integrative properties of stellate cells in the medial entorhinal cortex

    Hugh Pastoll, Derek L Garden ... Matthew F Nolan
    Setpoints that determine the integrative properties of neurons in the medial entorhinal cortex are established at a population level and differ between animals.
    1. Neuroscience

    Medial entorhinal cortex activates in a traveling wave in the rat

    J Jesús Hernández-Pérez, Keiland W Cooper, Ehren L Newman
    The existence of traveling waves in the medial entorhinal cortex, like those observed in the hippocampus, supports the hypothesis that traveling waves coordinate the activity of anatomically distributed circuits.
    1. Neuroscience

    Structural development and dorsoventral maturation of the medial entorhinal cortex

    Saikat Ray, Michael Brecht
    The medial entorhinal cortex is important for spatial memory formation and matures from dorsal, where smaller spatial-scales are represented, to ventral, where larger spatial-scales are represented.
    1. Neuroscience

    Deep learning-based feature extraction for prediction and interpretation of sharp-wave ripples in the rodent hippocampus

    Andrea Navas-Olive, Rodrigo Amaducci ... Liset M de la Prida
    A new method is described to identify sharp-wave ripples from the rodent hippocampus with deep learning techniques, which may help to identify and characterize previously undetected physiological events.
    1. Developmental Biology
    2. Evolutionary Biology

    Fgf-signaling is compartmentalized within the mesenchyme and controls proliferation during salamander limb development

    Sruthi Purushothaman, Ahmed Elewa, Ashley W Seifert
    While movement of Fgf-signaling to the limb mesenchyme accompanied a shift in function, the ultimate outcome remains a convergent tetrapod limb phenotype.

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