453 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter

    Smriti Mishra et al.
    The conformational cycle of an ABC heterodimeric transporter reveals a divergence in the structural mechanism of ABC exporters.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins

    Beth M Stadtmueller et al.
    The ectodomain of the human polymeric Ig receptor maintains a closed triangular shape that binds and excludes bacteria in mucosa, or opens to bind and transport polymeric Ig ligands across epithelial cells.
    1. Structural Biology and Molecular Biophysics

    Revealing an outward-facing open conformational state in a CLC Cl/H+ exchange transporter

    Chandra M Khantwal et al.
    The characterization of a previously unidentified “outward-facing open” conformational state provides a new framework for understanding the CLC transport mechanism.
    1. Epidemiology and Global Health

    Science Forum: Unit of analysis issues in laboratory-based research

    Nick R Parsons et al.
    A simulation study is used to demonstrate how mistakes in identifying the experimental unit and the unit of analysis can lead to incorrect analyses and inappropriate inferences when reporting research studies.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    ATP-induced asymmetric pre-protein folding as a driver of protein translocation through the Sec machinery

    Robin A Corey et al.
    How the process of protein folding may be controlled by the Sec machinery to assist protein transport across membranes.
    1. Cell Biology
    2. Developmental Biology

    Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration

    Lu Wei et al.
    Notch signaling controls the collective migration of parapineal cells through its capacity to restrict FGF pathway activation to a few leading cells.
    1. Computational and Systems Biology
    2. Neuroscience

    Discovering and deciphering relationships across disparate data modalities

    Joshua T Vogelstein et al.
    Multiscale Graph Correlation, an interpretable hypothesis test with strong theoretical guarantees for discerning relationships in complex data, requires about half the sample size as other methods, whilst maintaining computational tractability.
    1. Neuroscience

    Surface color and predictability determine contextual modulation of V1 firing and gamma oscillations

    Alina Peter et al.
    Colored surfaces induce strong gamma-synchronization yet sparse firing in V1 when receptive field inputs are predicted from the surrounding spatial context.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Spatial and temporal organization of RecA in the Escherichia coli DNA-damage response

    Harshad Ghodke et al.
    Phase separated DNA-free stored forms of RecA dissolve in response to DNA damage to make RecA available for repair and recombination reactions as part of the bacterial (Escherichia coli) SOS response.
    1. Neuroscience

    Functionally defined white matter of the macaque monkey brain reveals a dorso-ventral attention network

    Ilaria Sani et al.
    Primate attention is not limited to a dorsal fronto-parietal network, but includes a ventral temporal node and its dorso-ventral interactions with other attentional areas.

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